神经病学与神经康复学杂志2025，Vol.21Issue(4)：259-263,5.DOI:10.12022/jnnr.2024-0275
磷酸化Tau蛋白在早产儿脑损伤中的应用价值
The clinical significance of phosphorylated Tau protein in premature infants with brain injury
摘要
Abstract
Objective:To investigate the correlation between phosphorylated Tau at threonine 181(p-Tau 181)in peripheral blood and brain injury in premature infants. Methods:The p-Tau 181 level in the peripheral blood of premature infants was retrospectively analyzed.Twenty-eight premature infants were selected,including 13 in the brain injury group and 15 in the control group.The level of p-Tau 181 in peripheral blood was detected by Simoa assay. Results:The plasma level of p-Tau 181 in the brain injury group was significantly higher than that in the control group(P<0.05).The result of logistic regression analysis revealed that the elevated level of p-Tau 181 in plasma was an independent risk factor of brain injury. Conclusion:There may be overexpression of p-Tau 181 in plasma in premature infants with brain injury.关键词
Tau蛋白/磷酸化/早产儿/脑损伤Key words
Tau protein/Phosphorylation/Premature infants/Brain injury引用本文复制引用
蔡淑英,蔡建兴,林雅茵,胡恕香,彭桂兰..磷酸化Tau蛋白在早产儿脑损伤中的应用价值[J].神经病学与神经康复学杂志,2025,21(4):259-263,5.基金项目
福建省自然科学基金联合资金新上项目(2023J0111604) （2023J0111604）
厦门市医疗卫生指导性项目(3502Z20224ZD1218)New Project Funded by the Joint Fund of Fujian Provincial Natural Science Foundation(2023J0111604) （3502Z20224ZD1218）
Xiamen Medical and Health Guidance Project(3502Z20224ZD1218) （3502Z20224ZD1218）
