神经病学与神经康复学杂志2025，Vol.21Issue(4)：271-278,8.DOI:10.12022/jnnr.2025-0164
时间干扰刺激在精神疾病治疗中的研究进展
Research advances in temporal interference stimulation for psychiatric treatment
摘要
Abstract
In recent years,with the rapid development of interdisciplinary medicine and engineering,neuroregulation techniques have achieved unprecedented advancements.Among these innovations,non-invasive neuroregulation techniques,a form of non-invasive brain stimulation,characterized by high safety,good tolerance,favorable cost-effectiveness and simple operation,have been widely used in clinical practice.Although traditional electroconvulsive therapy(ECT)demonstrates well-established efficacy,its application is significantly limited by a tendency to induce whole-brain discharges and frequent association with notable cognitive side effects.In contrast,other non-invasive neuromodulation techniques,such as transcranial magnetic stimulation(TMS),transcranial direct current stimulation(tDCS)and transcranial alternating current stimulation(tACS),commonly face challenges including limited stimulation depth,difficulties in individualized implementation and suboptimal therapeutic outcomes.However,a novel non-invasive neuromodulation technique—temporal interference stimulation(TIS),holds promise for overcoming these limitations.Based on the biophysical mechanism of generating low-frequency envelope waves through cross-high-frequency electric fields,TIS achievies precise regulation of deep brain regions through non-vector integration,demonstrating potential to emerge as a mainstream clinical treatment for mental diseases.关键词
精神疾病/时间干扰刺激/无创神经调控/非侵入性脑刺激/个体化治疗Key words
Mental disease/Time interference stimulation/Non-invasive neuroregulation/Non-invasive brain stimulation/Individualized treatment引用本文复制引用
朱清峣,陈星,李卫军,焦雄,郑文思,李梦荧,王继军..时间干扰刺激在精神疾病治疗中的研究进展[J].神经病学与神经康复学杂志,2025,21(4):271-278,8.基金项目
南京医科大学康达学院科研发展基金(KD2024KYJJ307)Research Development Fund of Kangda College of Nanjing Medical University(KD2024KYJJ307) （KD2024KYJJ307）
