天津科技大学学报2025，Vol.40Issue(4)：1-11,50,12.DOI:10.13364/j.issn.1672-6510.20250044
抗肿瘤β-catenin/TCF拮抗剂的研究进展
Advances in Anti-Tumor β-catenin/TCF Antagonists
摘要
Abstract
The Wnt/β-catenin signaling pathway plays an important role in embryonic development,cancer stem cell homeostasis and tumorigenesis.β-Catenin,as the core protein of this pathway,is associated with various cancers due to its abnormal expression and function.Developing antagonists targeting the interaction between β-catenin and T-cell factor(TCF)has become an important direction for the development of anticancer drugs.In recent years,with the analysis of the crystal structure of β-catenin/TCF complex,breakthrough progress has been made in structure-based drug design,synthesis and screening.This article provides a classified review and outlook on small molecule antagonists targeting the β-catenin/TCF interaction,aiming to provide references for the development of innovative drugs targeting this pathway.关键词
抗肿瘤/Wnt信号通路/β-连环蛋白/T-细胞因子/小分子拮抗剂Key words
anti-tumor/Wnt signaling pathway/β-catenin/T-cell factor/small molecule antagonist分类
医药卫生引用本文复制引用
孙华,齐艺诺,刘璨..抗肿瘤β-catenin/TCF拮抗剂的研究进展[J].天津科技大学学报,2025,40(4):1-11,50,12.基金项目
国家自然科学基金项目(21502138) （21502138）
