武警医学2025，Vol.36Issue(8)：668-673,6.
长链非编码RNA SBF2-AS1在肝癌临床诊疗一体化中的应用价值
Application value of long non-coding RNA SBF2-AS1 in clinical theranostics of hepato-cellular carcinoma
摘要
Abstract
Objective To analyze the expression and clinical significance of long non-coding RNA SBF2-AS1(LncRNA SBF2-AS1)in hepatocellular carcinoma(HCC)tissues,and to explore its application value in theranostics of HCC.Methods A total of 54 patients with primary HCC admitted to the First Affiliated Hospital of Guangxi Medical University from 2021 to 2022 were selected as the study subjects.Postoperatively resected specimens from HCC and adjacent tissues were collected,along with multiple clinical treatment data,including pathological tissues,clinical laboratory diagnostics and treatment methods.The expres-sion level of LncRNA SBF2-AS1 in the tissue specimens were detected by real-time quantitative polymerase chain reaction(RT-qPCR)and analyzed for correlation with clinical diagnostic and therapeutic indicators using biostatistical methods.Bioinformatics databases were utilized to analyze the diagnostic value of LncRNA SBF2-AS1 for HCC.Results The relative expression level of LncRNA SBF2-AS1 in HCC tissues(10.656)was significantly higher than that in adjacent tissues(1.000),with a statistically significant difference(Z=-5.675,P＜0.001).The expression of LncRNA SBF2-AS1 was positively correlated with glutathione aminotransferase(r=0.297,P＜0.05),neutrophil(r=0.275,P＜0.05),and different treatment methods(r=0.332,P＜0.05).Patients were divided into a high expression group(27 patients)and a low expression group(27 patients)based on the median value of LncRNA SBF2-AS1 expression(M=3.649),and the expression level of LncRNA SBF2-AS1 was correlated with ghrelin transaminase(P＜0.05).The relative expression levels of LncRNA SBF2-AS1 in 371 cases of l HCC tissue and 50 cases of adja-cent tissues were obtained from the cancer genome atlas(TCGA)database.The area under the ROC curve(AUC)was 0.9122,with specificity of 94.00％and sensitivity of 79.51％.Conclusions LncRNA SBF2-AS1 is highly expressed in HCC tissues,which is related to alanine aminotransferase,neutrophils and treatment methods,and can serve as a biomarker for HCC diagnosis and inflammatory injury monitoring,demonstrating significant application value in clinical theranostics.关键词
肝癌/诊疗一体化/长链非编码RNA SBF2-AS1/应用价值Key words
hepatocellular carcinoma/theranostics/long non-coding RNA SBF2-AS1/application value分类
医药卫生引用本文复制引用
向冬云,赵莲,吴惠仪,孙昊,邓敬桓..长链非编码RNA SBF2-AS1在肝癌临床诊疗一体化中的应用价值[J].武警医学,2025,36(8):668-673,6.基金项目
国家自然科学基金(82060434) （82060434）
2024年广西研究生教育创新计划项目(YCSW2024260) （YCSW2024260）
