诊断学理论与实践2025，Vol.24Issue(4)：383-392,10.DOI:10.16150/j.1671-2870.2025.04.004
克罗恩病肠道纤维化的无创定量诊断研究进展
Research progress on noninvasive quantitative diagnosis of intestinal fibrosis in Crohn's disease
摘要
Abstract
Crohn's disease(CD)is a chronic,non-specific inflammatory bowel disease with complex etiology,often accompanied by progressive intestinal fibrosis during its course,which can ultimately lead to severe complications such as luminal stricture,obstruction,and fistula.The development of intestinal fibrosis is irreversible and shows limited response to anti-inflammatory therapies.Therefore,early identification and precise quantitative assessment of intestinal fibrosis are crucial for optimizing therapeutic strategies,delaying disease progression,reducing surgical risks,and improving long-term prognosis.In recent years,with the rapid development of imaging technologies,multiple noninvasive diagnostic modalities—including computed tomography enterography(CTE),magnetic resonance enterography(MRE),intestinal ultrasound(IUS),and positron emission tomography(PET)-CT/PET-MRE have become increasingly mature in clinical application.By inte-grating multidimensional approaches such as structural parameters,functional imaging,elastography,and radiomics-artificial intelligence models,the efficiency and accuracy of quantitative assessment of intestinal fibrosis have been signifi-cantly improved.This review systematically summarizes the research progress on quantitative imaging assessment tech-niques for CD-associated intestinal fibrosis,aiming to provide a theoretical basis and practical reference for the precise clinical management of CD fibrosis and the development of novel anti-fibrotic therapies.关键词
克罗恩病/肠道纤维化/定量诊断/无创评估/影像学评估Key words
Crohn's disease/Intestinal fibrosis/Quantitative diagnosis/Non-invasive assessment/Imaging evaluation分类
医药卫生引用本文复制引用
张平新,杨洁,王杨迪,陈旻湖,李雪华,毛仁..克罗恩病肠道纤维化的无创定量诊断研究进展[J].诊断学理论与实践,2025,24(4):383-392,10.基金项目
国家重点研发计划(2023YFC2507300) （2023YFC2507300）
国家自然科学基金(82222010,81970483) （82222010,81970483）
广东省重点领域研发计划(2023B1111040003) （2023B1111040003）
