诊断学理论与实践2025，Vol.24Issue(4)：401-406,6.DOI:10.16150/j.1671-2870.2025.04.006
《中国抗癌协会神经内分泌肿瘤诊治指南(2025年版)》更新精要:消化内镜诊疗解析
Key updates of China Anti-Cancer Association Guidelines for Diagnosis and Treatment of Neuroendocrine Neo-plasms(2025 Edition):Analysis of gastrointestinal endoscopic diagnosis and treatment
摘要
Abstract
Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)are the main type of neuroendocrine neoplasms(NENs).Their incidence rate has been increasing year by year,with variations in distribution across different regions and populations.The 2025 edition of the"Guidelines for Diagnosis and Treatment of Neuroendocrine Neoplasms"provides new guidance on endoscopic diagnosis and treatment of gastrointestinal NENs(GI-NENs).Based on comprehen-sive stratification criteria incorporating tumor size,pathological grading,and anatomical location,endoscopic submucosal dissection(ESD)and endoscopic mucosal resection(EMR)are recommended exclusively for G1 tumors with lesions≤10 mm in diameter,confined to the mucosa/submucosa without muscularis layer invasion or metastasis.For G2 neoplasms with lesions≤15 mm and Ki-67<10%,endoscopic intervention should be cautiously considered only for patients who cannot tolerate surgery.Digestive endoscopy,with its dual capabilities of visualized targeted biopsy and minimally invasive inter-vention,plays an important role in the diagnosis and treatment of GI-NENs.Endoscopic therapy is not simply a technical procedure,but requires a comprehensive decision-making process based on tumor staging,grading,systemic function evaluation,and molecular characteristics.Only through multidisciplinary collaboration,the in-depth integration of endoscopic precision evaluation,imaging examination,and systemic therapy,the construction of a whole-process management system,and the accumulation of evidence-based medical data can the limitations of heterogeneity be overcome and the diagnosis and treatment of NENs be advanced toward precision and personalization.关键词
神经内分泌肿瘤/指南/内镜/诊断/治疗Key words
Neuroendocrine neoplasms/Guidelines/Endoscopy/Diagnosis/Treatment分类
医药卫生引用本文复制引用
计蓓,苏薇,庹必光,刘雪梅..《中国抗癌协会神经内分泌肿瘤诊治指南(2025年版)》更新精要:消化内镜诊疗解析[J].诊断学理论与实践,2025,24(4):401-406,6.基金项目
国家自然科学基金(82470540,32460215) （82470540,32460215）
贵州省科技计划项目(黔科合平台人才HZJD[2021]001,黔科合基础-ZK[2023]重点059,黔科合平台人才CXTD[2023]001 （）
黔科合基础-ZK[2022]一般659) （）
贵州省高层次创新型人才"百层次人才"计划(黔科合平台人才-GCC[2023]043) （黔科合平台人才-GCC[2023]043）
