中国医院用药评价与分析2025，Vol.25Issue(8)：944-947,951,5.DOI:10.14009/j.issn.1672-2124.2025.08.009
安神补心六味丸联合美托洛尔对冠心病心绞痛合并焦虑抑郁患者的影响
Effects of Anshen Buxin Liuwei Pills Combined with Metoprolol on Patients with Coronary Heart Disease and Angina Pectoris Complicated with Anxiety and Depression
摘要
Abstract
OBJECTIVE:To explore the efficacy of Anshen Buxin Liuwei pills combined with metoprolol in the treatment of patients with coronary heart disease(CHD)and angina pectoris complicated with anxiety and depression,and provide scientific reference for clinical treatment.METHODS:A total of 240 patients with CHD and angina pectoris complicated with anxiety and depression admitted into the First Affiliated Hospital of Zhengzhou University from Feb.to Dec.2023 were extracted to be divided into the observation group(metoprolol+Anshen Buxin Liuwei pills),metoprolol control group(metoprolol),and placebo control group(metoprolol+placebo)by the random number table method,with 80 patients in each group.The frequency and duration of angina pectoris attacks,the degree of ST-segment depression and T-wave abnormalities on electrocardiogram(ECG)were compared among three groups before and after treatment.The Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)were used to evaluate the anxiety and depression status.The levels of inflammatory factors were detected.The Seattle Angina Questionnaire(SAQ)was used to evaluate the quality of life.Cardiac function indicators were measured.After one year of follow-up,the incidence of cardiovascular events and other long-term prognostic indicators such as mortality were recorded.Meanwhile,information such as patient's financial situation and degree of social support were collected to analyze the potential impact on the treatment outcome.RESULTS:After treatment,the observation group was significantly superior to the metoprolol control group and placebo control group in terms of the frequency and duration of angina pectoris attacks,the improvement of ECG,the reduction range of HAMA and HAMD scores,the decrease in levels of inflammatory factors,the increase in the scores of each dimension of SAQ,and the improvement of cardiac function indicators,with statistically significant differences(P<0.05).During the one-year follow-up,the incidence of cardiovascular events in observation group was 10.00%(8/80),significantly lower than that in the metoprolol control group(22.50%,18/80)and placebo control group(23.75%,19/80),the differences were statistically significant(P<0.05).The financial situation and degree of social support were correlated to a certain extent with treatment compliance and improvement in quality of life.CONCLUSIONS:Anshen Buxin Liuwei pills combined with metoprolol can more effectively relieve angina pectoris symptoms in patients with CHD and angina pectoris complicated with anxiety and depression,improve the anxiety and depression status,reduce the inflammatory response,enhance the quality of life,improve the cardiac function,and reduce the incidence of cardiovascular events,providing a better selection for clinical treatment.Meanwhile,financial situation and degree of social support have a certain impact on the treatment effect,which should be paid attention to in clinical treatment.关键词
安神补心六味丸/美托洛尔/冠心病/焦虑抑郁/联合治疗Key words
Anshen Buxin Liuwei pills/Metoprolol/Coronary heart disease/Anxiety and depression/Combined treatment分类
医药卫生引用本文复制引用
张力方,潘志刚,朱鹭冰,张丽媛,周霖..安神补心六味丸联合美托洛尔对冠心病心绞痛合并焦虑抑郁患者的影响[J].中国医院用药评价与分析,2025,25(8):944-947,951,5.基金项目
河南省科技攻关计划项目(No.242102311261) （No.242102311261）
河南省慢病防治与智慧健康管理重点实验室2024年度开放课题(No.ZYYC2024MB) （No.ZYYC2024MB）
河南省高等学校重点科研项目(No.25A320066) （No.25A320066）
