中国医院用药评价与分析2025，Vol.25Issue(8)：1020-1024,5.DOI:10.14009/j.issn.1672-2124.2025.08.026
特殊人群患者左乙拉西坦药动学特点及其药物浓度监测进展
Pharmacokinetics Characteristics of Levetiracetam and Its Therapeutic Drug Monitoring in Patients of Special Population
摘要
Abstract
Levetiracetam is a second-generation broad-spectrum antiepileptic drug that shows significant clinical efficacy in the treatment of various types of epilepsy,while significant pharmacokinetic variations have been observed when the drug is used in special populations(such as children,the elderly,pregnant women and patients with impaired renal function).Therefore,conducting therapeutic drug monitoring in such patients is helpful in maintaining the levetiracetam concentration within reference ranges,as well as improving its safety and efficacy.This article reviews relevant research progress on pharmacokinetics and blood concentrations monitoring of levetiracetam in special population,so as to provide reference for individualized medication in clinical special populations.关键词
左乙拉西坦/特殊患者/药动学/治疗药物监测Key words
Levetiracetam/Special patients/Pharmacokinetic/Therapeutic drug monitoring分类
医药卫生引用本文复制引用
刘燕,肖勇,华芳,谢毕阳,虞佳..特殊人群患者左乙拉西坦药动学特点及其药物浓度监测进展[J].中国医院用药评价与分析,2025,25(8):1020-1024,5.基金项目
江西省药品监督管理局科研项目(No.2021KY17) （No.2021KY17）
