湖南中医杂志2025，Vol.41Issue(8)：22-26,37,6.DOI:10.16808/j.cnki.issn1003-7705.2025.08.005
咳喘固本丸联合布地奈德福莫特罗粉吸入剂(Ⅱ)治疗AECOPD肺肾气虚证44例
Clinical effect of Kechuan Guben pills combined with budesonide/formoterol powder for inhalation(Ⅱ)in treatment of acute exacerbation of chronic obstructive pulmonary disease with lung-kidney Qi deficiency:An analysis of 44 cases
摘要
Abstract
Objective:To investigate the clinical effect of the self-made Chinese patent drug Kechuan Guben pills combined with budesonide/formoterol powder for inhalation(Ⅱ)in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with lung-kidney Qi deficiency.Methods:A total of 96 AE-COPD patients with lung-kidney Qi deficiency were enrolled and divided into treatment group and control group u-sing a random number table,with 48 patients in each group.The patients in the control group were given budes-onide/formoterol powder for inhalation(Ⅱ)and conventional treatment,while those in the treatment group were given Kechuan Guben pills in addition to the treatment in the control group;the course of treatment was 30 days for both groups.The two groups were compared in terms of the improvement in traditional Chinese medicine(TCM)syndrome,time to relief of symptoms,pulmonary function parameters[forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),and FEV1/FVC ratio],blood gas parameters[partial pressure of ox-ygen(PaO2)and partial pressure of carbon dioxide(PaCO2)],COPD assessment test score(CAT),modified British Medical Research Council Dyspnea Scale(mMRC),and modified Barthel index(MBI)score,and overall response was assessed based on TCM syndrome and pulmonary function parameters.Results:Finally 89 patients successfully completed the clinical study,with 44 patients in the treatment group and 45 patients in the control group.There was a significant difference in overall response rate between the treatment group and the control group[90.91％(40/44)vs 68.89％(31/45),P＜0.05].Compared with the control group,the treat-ment group had significantly better time to relief of symptoms,pulmonary function parameters(FEV1,FVC,and FEV1/FVC ratio),blood gas parameters(PaO2 and PaCO2),CAT score,mMRC score,and MBI score(P＜0.05).Conclusion:Kechuan Guben pills combined with budesonide/formoterol powder for inhalation(Ⅱ)can effectively improve clinical symptoms,pulmonary function,and activities of daily living in AECOPD patients with lung-kidney Qi deficiency,with a better clinical effect than budesonide/formoterol powder for inhalation(Ⅱ)used alone.关键词
慢性阻塞性肺疾病急性加重期/肺肾气虚证/咳喘固本丸/布地奈德福莫特罗吸入粉吸入剂(Ⅱ)Key words
acute exacerbation of chronic obstructive pulmonary disease/lung-kidney Qi deficiency/Kechuan Guben pills/budesonide/formoterol powder for inhalation(Ⅱ)分类
医药卫生引用本文复制引用
危致芊,杨辉红..咳喘固本丸联合布地奈德福莫特罗粉吸入剂(Ⅱ)治疗AECOPD肺肾气虚证44例[J].湖南中医杂志,2025,41(8):22-26,37,6.基金项目
湖南中医药大学校院联合基金项目(2022XYLH192) （2022XYLH192）
