东华大学学报（英文版）2025，Vol.42Issue(4)：339-347,9.DOI:10.19884/j.1672-5220.202404007
细菌纤维素/透明质酸口腔速溶膜的制备及性能
Preparation and Properties of Bacterial Cellulose/Hyaluronic Acid Oral Disintegrating Films
吴晓艳 1宋炜 1陈爽 1肖茹1
作者信息
- 1. 东华大学先进纤维材料全国重点实验室,材料科学与工程学院,上海 201620
- 折叠
摘要
Abstract
The oral disintegrating film(ODF)offers significant advantages such as superior patient compliance and rapid action onset as a form of solid drug delivery.However,the drug loading efficiency and dosage of the ODF currently available in the market are limited.To enhance the drug loading efficiency,with bacterial cellulose(BC)and hyaluronic acid(HA)as film-forming agents,glycerol(GL)as a plasticizer,and diprophylline(Dilor)as the model drug,a Dilor-ODF was prepared by a solvent casting method for the treatment of acute asthma-related diseases.The BC nano-network structure was utilized to augment the drug loading efficiency of the Dilor-ODF,while HA and GL were used to improve the elongation at break.The disintegration time,drug loading efficiency and drug releasing rate,and tensile properties of the Dilor-ODF were mainly evaluated.The results indicated that the Dilor-ODF exhibited a smooth surface with a uniform thickness and a maximum drug loading efficiency of(51.10±0.08)％.The time for complete disintegration and that for drug release in simulated oral saliva were less than 30 and 90 s,respectively,indicating the effect of rapid release.The tensile strength and elongation at break of the Dilor-ODF were(46.3±2.8)MPa and(1.9±0.2)％,respectively.The thermal decomposition temperature of the Dilor-ODF was higher than 200 ℃,satisfying subsequent processing demand.关键词
口腔速溶膜/细菌纤维素/透明质酸/溶剂浇铸法/二羟丙茶碱Key words
oral disintegrating film(ODF)/bacterial cellulose(BC)/hyaluronic acid(HA)/solvent casting method/diprophylline(Dilor)分类
医药卫生引用本文复制引用
吴晓艳,宋炜,陈爽,肖茹..细菌纤维素/透明质酸口腔速溶膜的制备及性能[J].东华大学学报（英文版）,2025,42(4):339-347,9.
