口腔疾病防治2025，Vol.33Issue(9)：757-764,8.DOI:10.12016/j.issn.2096-1456.202550185
口腔扁平苔藓与桥本甲状腺炎及其抗甲状腺抗体关联性的病例对照研究
A case-control study on the association of Hashimoto's thyroiditis and anti-thyroid antibodies with oral lichen planus
摘要
Abstract
Objective This study aims to explore the association between oral lichen planus(OLP)and Hashi-moto's thyroiditis(HT)and its anti-thyroid antibodies to provide clinical evidence for thyroid disease screening in pa-tients with OLP.Methods This study was approved by the institutional ethics committee.A total of 125 clinically and histopathologically confirmed patients with OLP were enrolled as the case group,and they were matched with 125 non-OLP controls based on sex and age.Demographic data(gender,age,lesion type,and disease duration)were collected from both groups.Serum levels of thyroid peroxidase antibodies(TPOAb)and thyroglobulin antibodies(TgAb)were mea-sured to analyze their associations with sex,age,lesion type,and disease duration in patients with OLP.Result The prevalence of HT in patients with OLP was 31.20%,significantly higher than that in the control group(9.60%)(χ2=18.504,P<0.001).The prevalence of HT in female patients with OLP(39.13%)was significantly higher than that in male patients(9.09%)(χ2=10.93,P<0.001).The positivity rate of thyroid peroxidase antibodies(TPOAb)in patients with OLP(17.6%)was significantly higher than in the control group(4.0%)(χ2=10.989,P<0.001).The TPOAb positiv-ity rate was significantly higher in female patients(22.83%)than in male patients(3.03%)(χ2=5.210,P=0.014).There was no statistically significant difference in the positivity rate of TgAb between patients with OLP(7.2%)and the con-trol group(3.2%)(P>0.05).Patients with erosive lesions had a significantly higher TPOAb positivity rate(25.0%,17/68)compared to those with non-erosive lesions(8.77%,5/57),and the difference was statistically significant(χ2=4.831,P=0.028).Logistic regression analysis revealed that female patients with OLP had an 8.935-fold higher risk of being TPOAb positive compared to males(OR=8.935,95%CI:1.134-70.388,P=0.038).Patients with erosive OLP lesions had a 3.199-fold higher risk of TPOAb positivity compared to those with non-erosive lesions(OR=3.199,95%CI:1.064-9.618,P=0.038).Conclusion The prevalence of HT is higher in patients with OLP,with higher positivity rates of anti-thyroid antibodies observed in female patients and those with erosive OLP lesions.This suggests that thyroid dis-ease screening should be incorporated into the clinical management of patients with OLP,especially for women and pa-tients who present with erosive lesions.关键词
口腔扁平苔藓/桥本甲状腺炎/自身免疫性疾病/抗甲状腺抗体/抗甲状腺过氧化物酶抗体/抗甲状腺球蛋白抗体/抗体滴度/糜烂型病变/免疫机制Key words
oral lichen planus/Hashimoto's thyroiditis/autoimmune diseases/anti-thyroid antibodies/thy-roid peroxidase antibodies/thyroglobulin antibodies/antibody titers/erosive lesions/immune mechanisms分类
医药卫生引用本文复制引用
刘媛,陈琰,从兆霞,李一鸣,薛瑞,赵今..口腔扁平苔藓与桥本甲状腺炎及其抗甲状腺抗体关联性的病例对照研究[J].口腔疾病防治,2025,33(9):757-764,8.基金项目
新疆维吾尔自治区青年科学基金(2022D01C253) This study was supported by the grant from the Youth Science Foundation of Xinjiang Uygur Autonomous Region(No.2022D01C253). （2022D01C253）
