口腔疾病防治2025，Vol.33Issue(9)：792-800,9.DOI:10.12016/j.issn.2096-1456.202440339
间充质干细胞来源外泌体的工程化及其在口腔医学领域的应用进展
Engineering of mesenchymal stem cell-derived exosomes and their application progress in the field of oral medicine
摘要
Abstract
In recent years,mesenchymal stem cell-derived exosomes(MSC-EXO)have garnered increasing attention in the field of stomatology and have become an established research area in biomedical research.This article reviews the engineering of exosomes derived from mesenchymal stem cells and their application in the field of stomatology,in order to provide new ideas for the development of stomatology.Exosomes are nanoscale membrane vesicles secreted by cells and contain a variety of proteins,RNAs,lipids,and other biomolecules.They are transported through the circula-tory system and can interact with other cells to regulate their biological behavior and participate in a variety of physi-ological and pathological processes.In the treatment of oral diseases,exosomes have shown great potential due to their natural biological activity and versatility.However,studies have found that relying solely on the function of natural exo-somes may not fully meet the complex clinical requirements.Therefore,the concept of engineered exosomes has emerged.Engineered exosomes can be modified by bioengineering technology to enhance their targeting,allowing them to reach the lesion site more accurately.At the same time,engineered exosomes can also be surface modified or loaded internally to carry specific therapeutic molecules,such as drugs,gene editing tools or signaling molecules to improve the therapeutic effect.In addition,this engineered treatment can also confer greater stability to exosomes,making them better able to resist clearance by the immune system when circulating in the body,extending their half-life,and improv-ing the effectiveness of treatment.Although engineered exosomes have attracted extensive attention in the fields of sto-matology and other fields,their application is still mainly in the stage of basic research.To promote the clinical applica-tion of engineered exosomes,it is necessary to provide more sufficient evidence of biocompatibility and clarify their therapeutic effect and mechanism.关键词
间充质干细胞/工程化外泌体/外泌体修饰/口腔医学/牙髓再生/牙周再生/骨再生/口腔癌/组织再生Key words
mesenchymal stem cell/engineered exosomes/exosome modification/stomatology/dental pulp regeneration/periodontal regeneration/bone regeneration/oral cancer/tissue regeneration分类
医药卫生引用本文复制引用
赵云峰,刘倩,李萌,李露颖,张薇,胡先同,马楚凡..间充质干细胞来源外泌体的工程化及其在口腔医学领域的应用进展[J].口腔疾病防治,2025,33(9):792-800,9.基金项目
国家自然科学基金面上项目(81970971) （81970971）
北京市自然科学基金面上项目(7232173) This study was supported by the grants from National Natural Science Foundation of China(No.81970971)and Beijing Municipal Natural Science Foundation(No.7232173). （7232173）
