口腔疾病防治2025，Vol.33Issue(9)：801-808,8.DOI:10.12016/j.issn.2096-1456.202550037
牙周致病菌诱导线粒体功能障碍促进牙周炎的研究进展
Research progress on periodontal pathogen inducing mitochondrial dysfunction promoting periodontitis
摘要
Abstract
Mitochondria,ubiquitous energy-producing organelles in eukaryotic cells,can have their normal func-tions disrupted by bacterial infections,leading to mitochondrial dysfunction.This dysfunction is closely associated with inflammatory diseases.Periodontitis,a chronic inflammatory disorder of periodontal tissues caused by pathogenic micro-organisms,has been increasingly linked to mitochondrial dysfunction in its pathogenesis and progression.Compared to healthy periodontal tissues,inflammatory lesions exhibit more pronounced mitochondrial dysfunction—a pathological process that is strongly correlated with periodontal pathogen infection.Studies reveal that these pathogens disrupt mito-chondrial homeostasis in host cells(e.g.,gingival epithelial cells and fibroblasts)through multiple mechanisms,includ-ing disrupting mitochondrial biogenesis,altering mitochondrial dynamics(promoting excessive fission),inhibiting mi-tophagy,impairing mitochondrial dysfunction-associated apoptosis,and inducing endogenous oxidative stress,which up-regulates pro-inflammatory cytokines.Collectively,these processes drive the establishment and persistence of an inflam-matory microenvironment.This review explores how periodontal pathogens affect mitochondrial function and their mechanistic contributions to periodontitis progression,with the goal of providing novel insights for developing mitochondria-targeted therapeutic strategies.关键词
线粒体/牙周炎/牙周致病菌/线粒体功能障碍/线粒体生物发生/线粒体动力学/线粒体自噬Key words
mitochondria/periodontitis/periodontal pathogen/mitochondrial dysfunction/mitochondrial bio-genesis/mitochondrial dynamics/mitophagy分类
医药卫生引用本文复制引用
李丽敏,彭显,周学东..牙周致病菌诱导线粒体功能障碍促进牙周炎的研究进展[J].口腔疾病防治,2025,33(9):801-808,8.基金项目
国家自然科学基金面上项目(32371523) This study was supported by the grants from the National Natural Science Foundation of China General Program(No.32371523) （32371523）
