口腔疾病防治2025，Vol.33Issue(9)：809-818,10.DOI:10.12016/j.issn.2096-1456.202550105
唾液腺黏膜相关淋巴组织淋巴瘤的研究进展
Research progress on salivary gland mucosa-associated lymphoid tissue lymphoma
摘要
Abstract
Salivary gland mucosa-associated lymphoid tissue lymphoma(SGML)is a subvariety of marginal zone B-cells that occurs outside of mucosal lymph nodes.The onset of SGML is closely related to immunity,chronic infections,and genetic factors,such as lymphoepithelial sialadenitis(LESA)and Sjogren's syndrome(SS),as well as Helicobacter pylori,hepatitis C virus,Epstein-Barr virus,and human T-lymphocytic virus.The most common site of SGML is the parotid gland,followed by the submandibular gland,small salivary gland,and sublingual gland.SGML is more common in middle-aged and elderly women,and patients often have autoimmune diseases,such as Sjogren's syndrome or rheu-matoid arthritis.SGML can be diagnosed through clinical manifestations,imaging,and histopathology,but histopatho-logical biopsy remains the main method for confirming SGML.Traditional treatment methods include anti-infective therapy and surgery combined with radiation or chemotherapy.In recent years,some new treatment methods,such as Bruton tyrosine kinase(BTK)inhibitors and programmed cell death protein-1(PD-1)inhibitors,have been effective against recurrent or refractory SGML,but more clinical trial data are needed to support them.At present,the optimal treatment for SGML is not yet clear.Individualized treatment plans should be developed based on the location,staging,clinical characteristics,and overall health status of the patient.SGML progresses slowly and has a relatively good over-all prognosis;however,the disease is recurrent,the treatment cycle is long,the recurrence rate is higher than that of other mucosa-associated lymphoid tissue lymphomas,and SGML may also cause other serious complications.Therefore,regular observation and follow-up are very important for its prognosis.This article reviews the etiology,diagnosis,treat-ment,and prognosis of SGML,with the aim of providing a reference for clinical diagnosis and treatment,and thus im-prove the survival rate of patients with SGML.关键词
唾液腺黏膜相关淋巴组织淋巴瘤/黏膜相关淋巴组织淋巴瘤/唾液腺恶性肿瘤/淋巴上皮性唾液腺炎/干燥综合征/淋巴瘤/发病机制Key words
salivary gland mucosa-associated lymphoid tissue lymphoma/mucosa-associated lymphoid tissue lym-phoma/salivary gland malignant tumor/lymphoepithelial sialadenitis/Sjögren's syndrome/lymphoma/patho-genesis分类
医药卫生引用本文复制引用
董佳琪,赵惠婷,罗观发,杨细虎..唾液腺黏膜相关淋巴组织淋巴瘤的研究进展[J].口腔疾病防治,2025,33(9):809-818,10.基金项目
国家自然科学基金面上项目(82173380) This study was supported by the grants from National Natural Science Foundation of China(No.82173380). （82173380）
