影像科学与光化学2025，Vol.43Issue(6)：41-47,102,8.DOI:10.7517/issn.1674-0475.2025.06.06
超声监测下早期肠内营养对重症患者胃肠排空障碍治疗效果的研究
Study on the Therapeutic Effect of Early Enteral Nutrition on Gastrointestinal Emptying Disorder in Severe Patients under Ultrasound Monitoring
摘要
Abstract
Objective:To investigate the clinical effect of early enteral nutrition(EEN)in the treatment of gastrointestinal emptying disorder in severe patients and its influence on ultrasound evaluation.Methods:A total of 40 severe patients with gastric emptying disorder who received EEN in the central ICU of Shanghai Fifth People's Hospital from June 2022 to May 2024 were selected by convenience sampling as the observation group,and 40 patients who did not receive EEN were included as the control group.Baseline data were collected from both groups,and the clinical therapeutic effect[Mini-nutrition Assessment(Simplified version)(MNA-SF)score before and after treatment],gastrointestinal emptying-related indexes[intestinal-fatty acid binding protein(I-FABP),vasoactive peptide(VIP)],antral ultrasound results[gastrointestinal emptying time(GET),antral contraction frequency(ACF),antral motor index(MI)],and intestinal tract functional ultrasound results(intestinal peristalsis,mucosal thickness of small intestine,mucosal thickness of colon),as well as oxidative stress-related indicators[reactive oxygen species(ROS),glutathione-peroxidase(GSH-PX),superoxide dismutase(SOD)]were compared between the two groups.Results:After treatment,the MNA-SF score of the observation group was significantly higher than that of the control group[(19.31±2.44)points vs.(16.05±2.17)points](P<0.05).The I-FABP level of the observation group was significantly lower than that of the control group[(28.04±6.46)ng/mL vs.(31.29±7.38)ng/mL](P<0.05),while the VIP level was significantly higher[(47.81±5.27)pg/mL vs.(43.18±5.08)pg/mL](P<0.05).The GET of the observation group was significantly shorter than that of the control group[(56.15±4.11)min vs.(64.10±5.08)min](P<0.05),and the ACF,MI,intestinal peristalsis,mucosal thickness of small intestine,and mucosal thickness of colon were significantly higher(P<0.05).The ROS level of the observation group was significantly lower than that of the control group[(581.61±58.91)U/mL vs.(618.05±61.52)U/mL](P<0.05),while the GSH-PX and SOD levels were significantly higher(P<0.05).Conclusion:This study confirms that EEN optimizes the gastrointestinal function and nutritional status of critically ill patients through a multi-dimensional regulatory mechanism,providing an important basis for clinical nutritional support strategies.关键词
早期肠内营养/胃肠排空障碍/胃肠超声/氧化应激Key words
early enteral nutrition/gastrointestinal emptying disorder/gastrointestinal ultrasound/oxidative stress分类
医药卫生引用本文复制引用
王洁,唐建国,姜俊杰,刘亚,许广杨..超声监测下早期肠内营养对重症患者胃肠排空障碍治疗效果的研究[J].影像科学与光化学,2025,43(6):41-47,102,8.基金项目
上海市科技计划项目(22ZR1448800) （22ZR1448800）
闵行区自然科学研究课题(2022MHZ056). （2022MHZ056）
