赣南医科大学学报2025，Vol.45Issue(8)：725-732,8.DOI:10.3969/j.issn.1001-5779.2025.08.001
E3泛素连接酶与炎症性肠病及结直肠癌的因果关联:一项孟德尔随机化研究
Causal association of E3 ubiquitin ligases with inflammatory bowel disease and colorectal cancer:a Mendel randomized study
摘要
Abstract
Objective:Exploring the causal relationship between E3 ubiquitin ligases(E3s)and Inflammatory bowel disease(IBD)and Colorectal cancer(CRC).Methods:The causal relationship between 25 E3s and IBD/CRC was studied through bidirectional Mendelian randomization(MR)and Bayesian weighted mendelian randomization(BWMR).The MR analysis was comprehensively evaluated using inverse variance weighting,MR-Egger regression,weighted median,simple mode and weighted mode,and was supplemented by sensitivity analysis such as heterogeneity test,horizontal pleiotropic test(MR-PRESSO and MR-Egger)and retention-one-based analysis to ensure the robustness of the results.Results:RNF13,RNF128 and ZNRF3 showed positive associations with IBD risk(OR=1.079,P=0.001;OR=1.075,P=0.023;OR=1.113,P=0.019).Notably,RNF13 demonstrated a marginally significant positive association with UC risk(OR=1.072,P=0.046),while ZNRF3 was significantly associated with increased CD risk(OR=1.291,P=0.005).For CRC,RNF8 exhibited a negative association(OR=0.906,P＜0.001),whereas RNF34 showed a positive association with increased risk(OR=1.081,P=0.016).Conclusion:The findings demonstrate causal relationships between RNF13,RNF128,ZNRF3 and IBD development(with RNF13 specifically associated with UC and ZNRF3 showing significant association with CD).Additionally,RNF8 was identified as a protective factor against CRC,while RNF34 was found to promote CRC risk.关键词
E3泛素连接酶/结直肠癌/炎症性肠病/孟德尔随机化Key words
E3 ubiquitin ligases/Colorectal cancer/Inflammatory bowel disease/Mendelian randomization分类
医药卫生引用本文复制引用
洛会,李雅菲,杨毅坚,郭添福,刘志平..E3泛素连接酶与炎症性肠病及结直肠癌的因果关联:一项孟德尔随机化研究[J].赣南医科大学学报,2025,45(8):725-732,8.基金项目
江西省教育厅科技重点项目(GJJ2401319) （GJJ2401319）
江西省自然科学基金重点项目(20242BAB26091) （20242BAB26091）
