国际老年医学杂志2025，Vol.46Issue(5)：523-528,6.DOI:10.3969/j.issn.1674-7593.2025.05.003
开颅术后ICU老年患者下肢深静脉血栓的危险因素预测效能研究
Study on the predictive efficacy of risk factors for lower extremity deep vein thrombosis in elderly icu patients post-craniotomy
摘要
Abstract
Objective To explore the risk factors,predictive efficacy of lower extremity deep venous thrombosis(DVT)in elderly patients after craniotomy admitted to the ICU.Methods A retrospective study was conducted in patients aged≥65 years after craniotomy admitted to the department of critical care medicine of Beijing Tiantan Hospital,Capital Medical University from June 2023 to June 2024.Patients were divided into a DVT group and a non-DVT group based on the results of lower extremity ultrasound examina-tions during their ICU stay.The incidence of lower extremity DVT was calculated.Relevant data from both groups was collected and compared.Multivariate logistic regression model was used to analyze the risk factors of DVT formation in elderly ICU patients after cra-niotomy,and a ROC curve was used to assess the predictive value of each index.Results A total of 190 elderly post-craniotomy pa-tients admitted to the ICU who completed lower extremity ultrasound examinations were included in the study.Among them,131 pa-tients were diagnosed with lower extremity DVT(DVT group,incidence rate:68.95%),while 59 patients showed no evidence of DVT(non-DVT group).Significant differences were observed between the two groups in Glasgow Coma Scale score,C-reactive protein,fi-brin degradation products,D-dimer,and fibrinogen levels(all P<0.05).Multivariate logistic regression analysis revealed that C-re-active protein and D-dimer were independent risk factors for lower extremity DVT in elderly ICU patients after craniotomy(P<0.05).ROC curve analysis indicated that CRP>50.07 mg/L[AUC(95%CI):0.597(0.505-0.689),P=0.033]and D-dimer>6.52 μg/mL[AUC(95%CI):0.802(0.738-0.867),P<0.001]were the optimal cutoff values for predicting DVT.Conclusion In elderly patients undergoing craniotomy and admitted to the ICU,C-reactive protein and D-dimer are independent predictors of lower extremity DVT.关键词
下肢深静脉血栓/开颅术后/C反应蛋白/D-二聚体/危险因素Key words
Lower extremity deep vein thrombosis/Post-craniotomy/C-reactive protein/D-dimer/Risk factors引用本文复制引用
杨涛,余姗姗..开颅术后ICU老年患者下肢深静脉血栓的危险因素预测效能研究[J].国际老年医学杂志,2025,46(5):523-528,6.基金项目
贵阳市科技计划项目([2024]2-24) （[2024]2-24）
