国际老年医学杂志2025，Vol.46Issue(5)：559-563,5.DOI:10.3969/j.issn.1674-7593.2025.05.009
营养控制状态评分对老年患者异基因造血干细胞移植治疗后并发口腔黏膜炎的预测价值
Controlling nutritional state score after allogeneic hematopoietic stem cell transplantation therapy for the elderly concurrent oral mucositis predictive value
摘要
Abstract
Objective To investigate the predictive value of controlling nutritional status score(CONUT)for oral mucositis after allogeneic hematopoietic stem cell transplantation in the elderly.Methods Eighty elderly patients who underwent allogeneic hematopoietic stem cell transplantation in the First Affiliated Hospital of Air Force Military Medical University from January 2021 to De-cember 2023 were selected as the study subjects and divided into oral mucositis group(n=24)and non-oral mucositis group(n=56)according to whether the patients had oral mucositis.ROC curve was used to analyze the predictive value of CONUT score for oral mucositis after allogeneic hematopoietic stem cell transplantation in the elderly;multivariate logistic regression was used to analyze the factors of oral mucositis after allogeneic hematopoietic stem cell transplantation in the elderly.Results There were statistically signifi-cant differences in disease types,use of methotrexate,use of glucocorticoids,and CONUT scores between the oral mucositis group and the non-oral mucositis group(P<0.05).Multivariate logistic regression analysis showed that the use of methotrexate,glucocorticoids,and CONUT score as independent risk factor for the development of oral mucositis(P<0.05),and plasma cell disease was an inde-pendent protective factor(P<0.05).The ROC curve of the CONUT score for predicting oral mucositis after allogeneic hematopoietic stem cell transplantation in the elderly showed that the AUC was 0.841(the 95%CI was 0.741 to 0.941,P<0.001),the sensitivity was 0.750,the specificity was 0.839,the maximum Youden index was 0.589,the optimal cut-off value was 6.94 points,indicates that it has good predictive value.Conclusion The CONUT score can be used as a predictive tool for the risk of oral mucositis in eld-erly patients after allogeneic hematopoietic stem cell transplantation,which has important clinical application value.关键词
异基因造血干细胞移植/口腔黏膜炎/营养控制状态评分/影响因素Key words
Allogeneic hematopoietic stem cell transplantation/Oral mucositis/Controlling nutritional status score/Influ-encing factors引用本文复制引用
王亚洁,王华萍,梁娜..营养控制状态评分对老年患者异基因造血干细胞移植治疗后并发口腔黏膜炎的预测价值[J].国际老年医学杂志,2025,46(5):559-563,5.基金项目
国家自然科学基金(81960916) （81960916）
