国际老年医学杂志2025，Vol.46Issue(5)：588-592,5.DOI:10.3969/j.issn.1674-7593.2025.05.014
伊伐布雷定联合托拉塞米治疗老年慢性心力衰竭的疗效及对相关指标的影响
Efficacy of ivabradine combined with torasemide in elderly patients with chronic heart failure and its effect on heart failure-related indices
摘要
Abstract
Objective To analyse the efficacy of ivbabradine in combination with torasemide in elderly patients with chronic heart failure(CHF)and its effect on heart failure-related indices.Methods The clinical data of 105 elderly patients with CHF admit-ted to the 960th Hospital of the PLA Joint Logistics Support Force from February 2021 to September 2023 were retrospectively analyzed and divided into the control group and the observation group according to different treatment methods.52 patients in the control group received torasemide treatment,and 53 patients in the observation group were treated with ivabradine on the basis of the control group.The efficacy,heart failure indicators,quality of life and safety were compared between the two groups.Results The effective rate in the observation group was higher than that in the control group(P<0.05).At 3 months of treatment,the levels of left ventricular e-jection fraction,vascular endothelial growth factor,and walking distance in 6 min in the two groups were higher than those before treat-ment,and in the observation group were higher than those in the control group(P<0.05),and the levels of left ventricular end-systol-ic diameter,N-terminal pro-brain natriuretic peptide precursor,cardiac troponin Ⅰ,serum nitric oxide,brain natriuretic peptide,and C-reactive protein levels and Minnesota living with heart failure questionnaire score in the two groups were higher than those before treatment,and in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In elderly patients with CHF,Iv-abradine combined with torasemide can significantly improve vascular endothelial function,cardiac function and myocardial indexes,reduce the degree of heart failure,and improve the quality of life of patients.关键词
慢性心力衰竭/伊伐布雷定/托拉塞米Key words
Chronic heart failure/Ivabradine/Torasemide引用本文复制引用
梁堃,高燕,刘科卫,栾明亚,刘超,朱春丽,李雅如..伊伐布雷定联合托拉塞米治疗老年慢性心力衰竭的疗效及对相关指标的影响[J].国际老年医学杂志,2025,46(5):588-592,5.基金项目
军队后勤科研项目保健专项课题(23BJZ45) （23BJZ45）
