中国妇幼健康研究2025，Vol.36Issue(9)：42-47,6.DOI:10.3969/j.issn.1673-5293.2025.09.007
子宫内膜异位症患者血清IGFBP-7、NGAL水平及对术后复发的预测价值
Serum levels of IGFBP-7 and NGAL of patients with endometriosis and their predictive values for postoperative recurrence of the disease
摘要
Abstract
Objective To detect serum levels of insulin-like growth factor binding protein 7(IGFBP-7)and neutrophil gelatinase associated lipocalin(NGAL)of patients with endometriosis(EMs)and to analyze their predictive values for postoperative recurrence of the disease.Methods A total of 106 EMs patients who admitted to Tangshan Municipal Maternal and Child Health Hospital from January 2019 to January 2020 were selected as EMs group.According to staging criteria for EMs of American Fertility Society(AFS),35 patients were diagnosed as stage Ⅰ of EMs,32 patients were diagnosed as stage Ⅱ of EMs,21 patients were diagnosed as stage Ⅲ of EMs and 18 patients were diagnosed as stage Ⅳ of EMs.A total of 106 healthy female volunteers who received physical health examination in our hospital in the same period were selected as control group.All EMs patients were followed up for three years after operation.60 patients recurred after operation(recurrence group,including 28 cases of stage Ⅱ of EMs,17 cases of stage Ⅲ of EMs and 15 cases of stage Ⅳ of EMs)and 46 patients didn't recur.Enzyme-linked immunosorbent assay(ELISA)was used to detect expression levels of serum IGFBP-7 and NGAL.Receiver operating characteristic(ROC)curve was used to analyze predictive values of serum IGFBP-7 and NGAL for postoperative recurrence in EMs patients.Results Compared with the control group,the expression levels of IGFBP-7 and NGAL in serum of EMs patients were higher,and the differences were statistically significant(t=24.077 and 24.362 respectively,both P＜0.05).The expression levels of IGFBP-7 and NGAL in EMs patients in stage Ⅰ group,stage Ⅱ group,stage Ⅲ group and stage Ⅳ group increased gradually,and the differences were statistically significant(F=35.170 and 30.837 respectively,both P＜0.05).Compared with the non-recurrence group,after operation,the expression levels of IGFBP-7 and NGAL in the recurrence group were higher,and the differences were statistically significant(t=14.206 and 8.876 respectively,both P＜0.05).The expression levels of IGFBP-7 and NGAL of the patients with stages Ⅱ,Ⅲ and Ⅳof EMs after operation were compared between the recurrence group and the non-recurrence group respectively,and the results showed that the expression levels of IGFBP-7 and NGAL in the recurrence group were higher than those in the non-recurrence group,and there were statistically significant differences(t=2.087 to 5.658,all P＜0.05).ROC curve showed that the area under the curve(AUC)of combination of IGFBP-7 and NGAL for predicting recurrence of EMs after operation was 0.927,which was higher than those predicted by single IGFBP-7 and single NGAL alone(Z=20.819 and 4.328 respectively,both P＜0.05).Conclusion The expression levels of IGFBP-7 and NGAL in serum of EMs patients increase significantly,and the combined detection of serum IGFBP-7 and NGAL levels had certain predictive value for postoperative recurrence of EMs in EMs patients.关键词
子宫内膜异位症/胰岛素样生长因子结合蛋白7/中性粒细胞明胶酶相关脂质运载蛋白/术后/复发Key words
endometriosis/insulin like growth factor binding protein 7/neutrophil gelatinase associated lipocalin/postoperative/recurrence分类
医药卫生引用本文复制引用
李梦雪,柴静,张家弘,杨利华..子宫内膜异位症患者血清IGFBP-7、NGAL水平及对术后复发的预测价值[J].中国妇幼健康研究,2025,36(9):42-47,6.基金项目
河北省医学科学研究课题计划(20231745) （20231745）
