中国实用神经疾病杂志2025，Vol.28Issue(9)：1137-1141,5.DOI:10.12083/SYSJ.240815
替罗非班给药方式在急诊老年颅内动脉瘤栓塞术中的效果及随访研究
Effect and follow-up study of tirofiban administration in elderly patients with emergency intracranial aneurysm embolization
摘要
Abstract
Objective To investigate the effect of different tirofiban administration methods in the embolization of emergency elderly intracranial aneurysms.Methods A total of 92 patients with acute thromboembolism who underwent intracranial aneurysm embolization in the Neurosurgery of Kunshan Hospital of Chinese Medicine from January 2019 to December 2023 were selected.They were divided into two groups with 46 cases in each group according to two injection routes of tirofiban.The control group was given intravenous injection,while the observation group was given intra-arterial injection.The incidence of perioperative complications in the two groups were recorded and the incidence rates of complications between the two groups were compared.The vascularization time and serum levels of interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)were compared between the two groups before and 3 days after operation.The patients were followed up 3 months after surgery,and the prognosis was evaluated by the modified Rankin scale(mRS).The prognosis of the two groups was compared.Results There was no significant difference in the incidence of perioperative complications between the two groups(6.52%vs 10.87%,P>0.05).The vascular recanalization time of the observation group was shorter than that of the control group((34.75±4.11)min vs(36.61±4.28)min,t=2.126,P=0.036).There were no significant differences in the levels of IL-6,CRP and TNF-α between the two groups before surgery(P>0.05),the levels of inflammatory factors in both groups increased(P<0.05),compared with the control group,the three indexes in the observation group were lower(P<0.05).After follow-up,the proportion of good prognosis 3 months after operation in the observation group was higher than that in the control group(95.65%vs 82.61%,χ 2=4.039,P=0.044).Conclusion Both different administration methods of tirofiban in intracranial aneurysm embolization are safe and effective.Compared to intravenous injection,arterial infusion can shorten the vascular recanalization time and reduce inflammatory response more effectively.关键词
颅内动脉瘤/替罗非班/动脉灌注/静脉注射/动脉瘤栓塞术/急性血栓栓塞Key words
Intracranial aneurysms/Tirofiban/Arterial perfusion/Intravenous injection/Aneurysm embolization/Acute thromboembolism分类
医药卫生引用本文复制引用
阮敏,仝允逸,朱胜强,王文华..替罗非班给药方式在急诊老年颅内动脉瘤栓塞术中的效果及随访研究[J].中国实用神经疾病杂志,2025,28(9):1137-1141,5.基金项目
江苏省中医药科技发展计划项目(编号:MS2021064) （编号:MS2021064）
