中国实用神经疾病杂志2025，Vol.28Issue(9)：1178-1183,6.DOI:10.12083/SYSJ.240440
自身免疫性脑炎早期诊断的研究进展
Research progress in early diagnosis of autoimmune encephalitis
摘要
Abstract
Autoimmune encephalitis(AE)is an inflammatory syndrome affecting the central nervous system,triggered by autoantibodies.Depending on the antibody type,AE is categorized into three subtypes:anti-cell surface antigen,anti-intracellular synaptic antigen,and anti-intracellular antigen antibodies encephalitis.Notably,anti-NMDAR encephalitis is the most prevalent among these.Given the intricate nature of AE,its wide range of clinical presentations,and the diverse antibody types involved,early diagnosis coupled with prompt intervention holds the key to improving patient outcomes and minimizing recurrence.Currently,neuronal antibody detection serves as the primary diagnostic tool for AE.However,this approach is hindered by drawbacks,such as lengthy processing times and elevated false negative rates influenced by subjective factors.Moreover,a considerable proportion of AE cases remain undiagnosed due to the absence of detectable antibodies,highlighting an urgent need for alternative diagnostic methods.This article focusing on anti-NMDAR encephalitis as a case study,aims to underscore the significance of early diagnosis in AE.It accomplishes this through an analysis of clinical manifestations,an evaluation of 18F-FDG PET/CT imaging techniques,and the identification of potential biomarkers.By synthesizing these perspectives,the article offers novel insights and directions to inform early diagnosis for AE.关键词
自身免疫性脑炎/抗NMDAR脑炎/早期诊断/临床表现/生物标志物Key words
Autoimmune encephalitis/Anti-NMDAR encephalitis/Early diagnosis/Clinical presentation/Biomarkers分类
医药卫生引用本文复制引用
徐凯玥,田璟鸾,薛群..自身免疫性脑炎早期诊断的研究进展[J].中国实用神经疾病杂志,2025,28(9):1178-1183,6.基金项目
国家自然科学基金面上项目(编号:82371365) （编号:82371365）
苏州大学校级协同创新中心(横向科研项目)(编号:H230028) （横向科研项目）
江苏省自然科学基金面上项目(编号:BK20211075) （编号:BK20211075）
