临床与病理杂志2025，Vol.45Issue(6)：720-724,5.DOI:10.11817/j.issn.2095-6959.2025.250149
HOXC9在恶性肿瘤中作用的研究进展
Research progress in the role of HOXC9 in malignant tumors
摘要
Abstract
Homeobox (HOX) genes encode a highly conserved family of transcription factors containing homeodomains. HOX proteins regulate multiple pathways during normal cell development,including cell division,adhesion,proliferation,apoptosis,and differentiation. Homeobox C9 (HOXC9) is an important member of the HOX gene family and is associated with the cell cycle,differentiation,migration,and other biological processes. In recent years,research on HOXC9 in tumor biology has increased,and its biological functions have received wide attention.HOXC9 is abnormally expressed in various malignant tumors and is closely related to tumor occurrence,progression,invasion,metastasis,and prognosis.For example,high HOXC9 expression is significantly associated with tumor staging in hepatocellular carcinoma and with the 5-year survival rate in gastric cancer.However,the role and mechanisms of HOXC9 in the initiation and progression of malignant tumors have not yet been fully elucidated,particularly the cross-cancer regulatory mechanisms involving epithelial-mesenchymal transition(EMT)related proteins.Systematically investigating HOXC9 expression patterns and mechanisms across different types of malignant tumors,and exploring the potential of combining immunohistochemical detection of EMT markers for clinical application,has significant scientific and clinical value.关键词
同源框基因/同源框C9/恶性肿瘤/上皮-间充质转化/预后Key words
homeobox genes/homeobox C9/malignant tumors/epithelial-mesenchymal transition/prognosis引用本文复制引用
王桃丽,杨明秀,王子怡,鲁广建..HOXC9在恶性肿瘤中作用的研究进展[J].临床与病理杂志,2025,45(6):720-724,5.基金项目
株洲市科学技术局社会化出资项目(株科办〔2024〕1号).This work was supported by the Social Investment Project of Zhuzhou Science and Technology Bureau,China(Zhuzhou Science and Technology Bureau Office〔2024〕No.1). （株科办〔2024〕1号）
