临床与病理杂志2025，Vol.45Issue(6)：760-765,6.DOI:10.11817/j.issn.2095-6959.2025.250118
结直肠颗粒细胞瘤的临床病理特征
Clinicopathological features of colorectal granular cell tumors
摘要
Abstract
Objective:Granular cell tumor(GCT)is a rare soft tissue tumor originating from neural crest cells,and its occurrence in the colorectum is even rarer.This study aims to investigate the clinicopathological features of colorectal GCT. Methods:Clinical data of 4 patients pathologically diagnosed with colorectal GCT were retrospectively analyzed,including patient's gender,tumor site,endoscopic findings,clinicopathological features,immunohistochemical results,and follow-up outcomes. Results:The male-to-female ratio was 3꞉1.Tumors were located in the ileocecal region,cecum,transverse colon,and rectum.Under endoscopy,2 cases appeared as broad-based polyps and 2 as submucosal protrusions,with tumor diameters of 0.6 to 0.8 cm.Histologically,2 cases were confined to the submucosa,while 2 involved both mucosa and submucosa.The tumors were arranged in nests or sheets,with tumor cells being round or polygonal and having eosinophilic granular cytoplasm.Two cases showed locally infiltrative growth,while 2 had well-defined borders.One case each was accompanied by a tubular adenoma of the ascending colon,sigmoid colon,and polypoid mucosal hyperplasia of the sigmoid colon.Immunohistochemistry showed positivity for sex determining region Y-box 10(SOX10)(3/3),S100 protein(4/4),cluster of differentiation 68(CD68)(3/4),neuron-specific enolase(NSE)(1/2),alpha-inhibin(α-inhibin)(1/4),and transcription factor E3(TFE3)(3/3).The tumors were negative for cytokeratin(CK)(0/2),discovered on gastrointestinal stromal tumors-1(Dog-1)(0/2),chromogranin A(CgA)(0/1),human melanoma black 45(HMB-45)(0/1),and melanoma antigen recognized by T-cells 1(Melan-A)(0/1).All tumors were removed under the endoscope.During a follow-up of 9 to 25 months,no recurrence or metastasis was observed. Conclusion:Colorectal granular cell tumors are rare and need to be differentiated from various other tumors.Immunohistochemistry is helpful for differential diagnosis.关键词
结肠/回盲肠/直肠/颗粒细胞瘤/免疫组织化学Key words
colon/ileocecum/rectum/granular cell tumor/immunohistochemistry引用本文复制引用
李婷,贺崇芳,顾文贤,陈颖婷,程羽青..结直肠颗粒细胞瘤的临床病理特征[J].临床与病理杂志,2025,45(6):760-765,6.基金项目
常州市"十四五"卫生健康高层次人才培养工程(2022CZBJ079) （2022CZBJ079）
常州市科技局社会发展项目(CE20235064).This work was supported by the High-Level Talent Training Program of Health Sector during the 14th Five-Year Plan Period of Changzhou(2022CZBJ079)and the Social Development Project of Changzhou Science and Technology Bureau(CE20235064),China. （CE20235064）
