解剖学杂志2025，Vol.48Issue(4)：319-324,6.DOI:10.3969/j.issn.1001-1633.2025.04.009
非小细胞肺癌组织中KDM5B、KLK11、PROX1表达与临床病理特征及预后的关系
Correlation of the expression of KDM5B,KLK11,PROX1 in non-small cell lung cancer tissues with clinical pathological characteristics and prognosis
摘要
Abstract
Objective:To investigate the associations of the expression of histone lylsine demethylase 5B(KDM5B),kallikrein(KLK)11,and prospero-related homeobox 1(PROX1)in non-small cell lung cancer(NSCLC)tissues with the clinical pathological characteristics and prognosis.Methods:NSCLC patients admitted to the Nanyang Central Hospital from July 2019 to June 2021 were selected as the study subjects.Immunohistochemistry was applied to detect the expression of KDM5B,KLK11,and PROX1 in cancer tissues and adjacent tissues.Patients were classified into deceased or surviving cohorts based on 3-year follow-up data.Multivariate Cox regression was applied to analyze the influencing factors of NSCLC prognosis.Kaplan-Meier curve was applied to analyze the relationship between the expression of KDM5B,KLK11,PROX1 with the prognosis of NSCLC.Results:The positive expression rates of KDM5B,KLK11,and PROX1 in cancer tissues were obviously higher than those in adjacent tissues.The tumor diameter of NSCLC patients was related to the expression of KDM5B and PROX1,while the elevated expression of all three markers was associated with advanced TNM stage and lymph-node metastasis.Compared with the survival group,the proportions of TNM stage Ⅲ and lymph node metastasis in the death group were obviously higher.Compared with the survival group,the positive expression rates of KDM5B,KLK11,and PROX1 were obviously higher in the cancer tissues in the death group.Multivariate Cox regression showed that TNM stage Ⅲ(OR=2.369),lymph node metastasis(OR=1.843),KDM5B positivity(OR=2.014),KLK11 positivity(OR=1.562),and PROX1 positivity(OR=1.986)were all risk factors for poor prognosis in NSCLC.Patients positive for KDM5B,KLK11,or PROX1 had significantly lower 3-year OS than their negative counterparts(Log-rank x2=11.108,8.468,and 10.697,respectively).Conclusion:KDM5B,KLK11,and PROX1 have high positive expression rates in NSCLC tissues,and their expression levels are closely related to the pathological characteristics and prognosis of NSCLC.关键词
非小细胞肺癌/肿瘤分期/预后/组蛋白去甲基化酶5B/激肽释放酶11/prospero同源异形盒蛋白1Key words
non-small cell lung cancer/tumor staging/prognosis/histone demethylase 5B/kallikrein 11/prospero-related homeobox 1分类
医药卫生引用本文复制引用
金博,崔勇俊,韩彬,曲伟伟,李博..非小细胞肺癌组织中KDM5B、KLK11、PROX1表达与临床病理特征及预后的关系[J].解剖学杂志,2025,48(4):319-324,6.基金项目
河南省医学科技攻关联合共建项目(LHGJ202206118) （LHGJ202206118）
