实用临床医药杂志2025，Vol.29Issue(15)：12-16,5.DOI:10.7619/jcmp.20251891
子宫内膜癌患者血清血管内皮生长因子、转化生长因子-β、白细胞介素-1、白细胞介素-6水平与临床病理特征的关系
Relationships of serum levels of vascular endothelial growth factor,transforming growth factor-β,interleukin-1,and interleukin-6 with clinicopathological features in patients with endometrial cancer
摘要
Abstract
Objective To analyze the changes in serum levels of cancer-associated fibroblast-re-lated factors[vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1)]and inflammatory mediators[interleukin-1(IL-1),interleukin-6(IL-6)]in patients with endometrial cancer(EC)and their relationship with clinicopathological features.Methods A total of 180 pa-tients with EC were selected as EC group,and 100 patients with benign endometrial lesions who visi-ted the hospital during the same period were selected as control group.The serum levels of VEGF,TGF-β1,IL-1 and IL-6 were compared between the two groups,as well as among EC patients with different clinicopathological features.Spearman correlation analysis was used to examine the relation-ship between the above-mentioned serum indicators and clinicopathological features in EC patients.Results The serum levels of VEGF,TGF-β1,IL-1 and IL-6 in the EC group were higher than those in the control group,with statistically significant differences(P＜0.05).The serum levels of VEGF,TGF-β1,IL-1 and IL-6 in EC patients with a myometrial invasion depth ≥ 1/2 and lymph node metas-tasis were higher than those in EC patients with a myometrial invasion depth＜1/2 and no lymph node metastasis(P＜0.05).Spearman correlation coefficient analysis showed that the serum levels of VEGF,TGF-β1,IL-1 and IL-6 in EC patients were positively correlated with myometrial invasion depth and lymph node metastasis status,respectively(P＜0.05).Conclusion The serum levels of VEGF,TGF-β1,IL-1 and IL-6 are significantly elevated in EC patients.These indicators are sig-nificantly correlated with clinicopathological features and have potential value in the early diagnosis,prognosis assessment,and targeted therapy of EC.关键词
子宫内膜癌/癌相关成纤维细胞/血管内皮生长因子/转化生长因子-β1/白细胞介素-1/白细胞介素-6/临床病理特征/肿瘤微环境Key words
endometrial cancer/cancer-associated fibroblasts/vascular endothelial growth factor/transforming growth factor-β1/interleukin-1/interleukin-6/clinicopathological features/tumor microenvironment分类
医药卫生引用本文复制引用
杨雅琴,李佳慧,赵莉萍..子宫内膜癌患者血清血管内皮生长因子、转化生长因子-β、白细胞介素-1、白细胞介素-6水平与临床病理特征的关系[J].实用临床医药杂志,2025,29(15):12-16,5.基金项目
内蒙古自治区卫生健康科技计划项目(202201496) （202201496）
