实用临床医药杂志2025，Vol.29Issue(15)：28-34,7.DOI:10.7619/jcmp.20252010
外周血BUB1B和KIF11预测非肌层浸润性膀胱癌患者经尿道膀胱肿瘤电切术后复发的价值
Values of BUB1B and KIF11 in peripheral blood in predicting recurrence after transurethral resection of bladder tumor for patients with non-muscle-invasive bladder cancer
摘要
Abstract
Objective To investigate the relationships of the expression levels of BUB1 mitotic checkpoint serine/threonine kinase B(BUB1B)and kinesin family member 11(KIF11)in peripher-al blood with postoperative recurrence in non-muscle-invasive bladder cancer(NMIBC)patients trea-ted with transurethral resection of bladder tumor(TURBT).Methods A retrospective case-control study design was employed.A total of 188 NMIBC patients who received standard TURBT treatment in the 215th Hospital of Shaanxi Nuclear Industry during initial visit from January 2019 to December 2021 were selected as research objects.Patients were followed up for 36 months and divided into re-currence group(n=68)and non-recurrence group(n=120)based on pathological examination re-sults.Additionally,50 healthy individuals who underwent physical examinations during the same period were selected as control group.The levels of BUB1B mRNA and KIF11 mRNA in peripheral blood were compared among the recurrence group,non-recurrence group,and control group.Clinical data were compared between the recurrence and non-recurrence groups.Cox proportional hazards regression models were used to analyze the postoperative follow-up data of NMIBC patients with TURBT.Kaplan-Meier plots were drawn to assess the proportional hazards assumption(PH assumption)of the Cox model.The predictive efficacy of various indicators for postoperative recurrence in NMIBC patients was eval-uated using receiver operating characteristic(ROC)curve.Results The levels of BUB1B mRNA and KIF11 mRNA in peripheral blood in the control group,non-recurrence group,and recurrence group sucessively increased(P＜0.001).The recurrence group had a significantly higher number of patients with pathological T1 staging and multiple tumors compared to the non-recurrence group(P＜0.05).The Kaplan-Meier curves for the number of tumors,pathological staging,BUB1B mRNA,and KIF11 mRNA levels were generally parallel to recurrence rates between the two groups,meeting PH assumption.Multiple tumors,pathological T1 staging,BUB1B mRNA,and KIF11 mRNA levels were independent influencing factors for recurrence in NMIBC patients after TURBT treatment(P＜0.05).ROC curve analysis showed that the areas under the curves(AUCs)for predicting postoper-ative recurrence in NMIBC patients by multiple tumors,pathological T1 staging,BUB1B mRNA,and KIF11 mRNA levels were 0.674,0.746,0.610 and 0.642,respectively.The combined pre-diction using these indicators yielded an AUC of 0.826(95％CI,0.767 to 0.884),with a sensitiv-ity of 86.80％and a specificity of 75.30％,indicating good predictive efficacy.Conclusion Ele-vated levels of BUB1B mRNA and KIF11 mRNA in peripheral blood are significantly associated with postoperative recurrence in NMIBC patients after TURBT and serve as independent risk factors for recurrence.As non-invasive biomarkers,BUB1B mRNA and KIF11 mRNA in peripheral blood com-bined with clinical parameters can significantly improve the predictive efficacy of postoperative recur-rence,providing a new strategy for individualized monitoring.关键词
非肌层浸润性膀胱癌/BUB1有丝分裂检查点丝氨酸/苏氨酸激酶B/驱动蛋白家族成员11/经尿道膀胱肿瘤电切术/预后/分子标志物/复发/多发肿瘤Key words
non-muscle-invasive bladder cancer/BUB1 mitotic checkpoint serine/threonine kinase B/kinesin family member 11/transurethral resection of bladder tumor/prognosis/molecular biomarker/recurrence/multiple tumors分类
医药卫生引用本文复制引用
王辉,李占琦,赵少雄..外周血BUB1B和KIF11预测非肌层浸润性膀胱癌患者经尿道膀胱肿瘤电切术后复发的价值[J].实用临床医药杂志,2025,29(15):28-34,7.基金项目
陕西省卫生健康委科研项目(2024-SFY1062) （2024-SFY1062）
