实用临床医药杂志2025，Vol.29Issue(15)：47-51,57,6.DOI:10.7619/jcmp.20252562
人乳头瘤病毒E6/E7 mRNA联合阴道镜检查在宫颈癌及癌前病变筛查中的价值
Value of human papillomavirus E6/E7 mRNA combined with colposcopy in screening cervical cancer and precancerous lesions
摘要
Abstract
Objective To evaluate the efficacy of human papillomavirus E6/E7(HPV E6/E7)mRNA combined with colposcopy in screening cervical cancer and precancerous lesions.Methods A total of 480 patients with suspected cervical precancerous lesions in the hospital from July 2022 to De-cember 2024 were retrospectively selected as research objects.All the patients underwent HPV E6/E7 mRNA testing,colposcopy,and pathological examination.Taking the pathological examination results as the diagnostic golden standard,the diagnostic values of HPV E6/E7 mRNA and colposcopy alone as well as their combination were analyzed.Results The pathological examination results of 480 pa-tients showed that there were 192 negative cases,including 1 case of normal cervix and 191 cases of benign lesions;there were 288 positive cases,including 133 cases of low-grade squamous intraepithe-lial lesions(LSIL),110 cases of high-grade squamousintraepithelial lesions(HSIL),and 45 cases of cervical squamous cell carcinoma(SCC).The colposcopy results showed 211 true-positive cases and 138 true-negative cases;the HPV E6/E7 mRNA test results showed 199 true-positive cases and 137 true-negative cases;the combined test results showed 239 true-positive cases and 174 true-negative cases.The sensitivity(95.22％),specificity(75.98％),accuracy(86.04％),positive predic-tive value(81.29％),and negative predictive value(93.55％)of the combined test were signifi-cantly higher than those of each individual test(P＜0.001).Moreover,the consistency between the combined test and pathological results(Kappa=0.718,P＜0.001)was also significantly high-er than that of each individual test.Conclusion Compared with HPV E6/E7 mRNA or colposcopy alone,the combined test has higher clinical application value in screening of cervical precancerous lesions and cervical cancer,shows stronger consistency with pathological results,and is of great sig-nificance for the early differential diagnosis of cervical precancerous lesions and cervical cancer.关键词
宫颈癌前病变/宫颈癌/人乳头瘤病毒/阴道镜/诊断效能/临床筛查/鳞状上皮内病变/宫颈鳞状细胞癌Key words
cervical precancerous lesions/cervical cancer/human papillomavirus/colpos-copy/diagnostic efficacy/clinical screening/squamous intraepithelial lesions/cervical squamous cell carcinoma分类
医药卫生引用本文复制引用
谢凌云,陆红梅,徐扬,凌玲,尹静,杨靖,程文国..人乳头瘤病毒E6/E7 mRNA联合阴道镜检查在宫颈癌及癌前病变筛查中的价值[J].实用临床医药杂志,2025,29(15):47-51,57,6.基金项目
江苏省卫健委预防医学项目(Ym2023028) （Ym2023028）
江苏省扬州市科技计划项目(YZ2023107) （YZ2023107）
