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Deciphering the roles of neddylation modification in hepatocellular carcinoma:Molecular mechanisms and targeted therapeutics

Wenxin Wu Xuanyi Wang Ruijie Ma Shuhong Huang Hongguang Li Xinxing Lyu

基因与疾病(英文)2025,Vol.12Issue(4):342-357,16.
基因与疾病(英文)2025,Vol.12Issue(4):342-357,16.DOI:10.1016/j.gendis.2024.101483

Deciphering the roles of neddylation modification in hepatocellular carcinoma:Molecular mechanisms and targeted therapeutics

Deciphering the roles of neddylation modification in hepatocellular carcinoma:Molecular mechanisms and targeted therapeutics

Wenxin Wu 1Xuanyi Wang 1Ruijie Ma 2Shuhong Huang 3Hongguang Li 4Xinxing Lyu5

作者信息

  • 1. School of Clinical and Basic Medical Sciences,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250117,China
  • 2. Department of Thoracic Surgery,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China
  • 3. School of Clinical and Basic Medical Sciences,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250117,China||Science and Technology Innovation Center,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250117,China
  • 4. Department of Hepatobiliary Surgery,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250021,China
  • 5. Hospital for Skin Diseases,Shandong First Medical University,Jinan,Shandong 250117,China||School of Clinical and Basic Medical Sciences,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250117,China||Science and Technology Innovation Center,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250117,China
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摘要

关键词

Cancer therapy/Hepatocellular carcinoma/Neddylation/Post-translation modification/Targeted inhibitors

Key words

Cancer therapy/Hepatocellular carcinoma/Neddylation/Post-translation modification/Targeted inhibitors

引用本文复制引用

Wenxin Wu,Xuanyi Wang,Ruijie Ma,Shuhong Huang,Hongguang Li,Xinxing Lyu..Deciphering the roles of neddylation modification in hepatocellular carcinoma:Molecular mechanisms and targeted therapeutics[J].基因与疾病(英文),2025,12(4):342-357,16.

基金项目

This work was supported by the Natural Science Foundation of Shandong Province,China(No.ZR2021QC030,ZR2022LZL006)and the Innovation Project of Shandong First Medical University. (No.ZR2021QC030,ZR2022LZL006)

基因与疾病(英文)

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