实用临床医药杂志2025，Vol.29Issue(16)：40-45,6.DOI:10.7619/jcmp.20251992
血清Nod样受体蛋白3、降钙素基因相关肽以及内皮型一氧化氮合酶预测脑出血开颅手术后继发颅内感染及预后的价值
Predictive values of serum Nod-like receptor protein 3,calcitonin gene-related peptide and endothelial nitric oxide synthase for secondary intracranial infection and prognosis following craniotomy for cerebral hemorrhage
摘要
Abstract
Objective To investigate the predictive value of serum Nod-like receptor protein 3(NLRP3),calcitonin gene-related peptide(CGRP),and endothelial nitric oxide synthase(eNOS)for secondary intracranial infection and prognosis following craniotomy for cerebral hemorrhage.Meth-ods A case-control study was conducted.A total of 70 patients with secondary intracranial infection after craniotomy for cerebral hemorrhage in the hospital from January 2021 to May 2024 were selected as observation group,and 210 patients without secondary intracranial infection after craniotomy for cer-ebral hemorrhage were selected as control group.Surgical conditions and serum levels of NLRP3,CGRP,and eNOS were compared between the two groups,and clinical differences between died and surviving patients in the observation group were analyzed.Results The observation group had signifi-cantly higher rates of tracheal intubation and surgical duration exceeding 4 hours,along with significant elevated serum levels of NLRP3,CGRP,and eNOS compared to the control group(P＜0.001).Logistic regression analysis revealed that tracheal intubation,NLRP3,CGRP,and eNOS were influ-encing factors for secondary intracranial infection(P＜0.05).In the observation group,there were 18 deaths and 52 survivors.The death group had significantly higher age,the Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,and serum levels of NLRP3,CGRP,and eNOS compared to the surviving group(P＜0.05).Logistic regression analysis indicated that APACHE Ⅱ score and serum levels of NLRP3,CGRP,and eNOS were influencing factors for mor-tality in patients with secondary intracranial infection(P＜0.05).The areas under the curve of the receiver operating characteristic(ROC)curves for serum NLRP3,CGRP,and eNOS in predicting secondary intracranial infection were 0.805,0.784,and 0.735 respectively,with significant differ-ences(P＜0.001).The areas under the curve of ROC curves for serum NLRP3,CGRP,and eNOS in predicting mortality in patients with secondary intracranial infection were 0.684,0.763,and 0.763,respectively,with significant differences(P＜0.05).Conclusion Serum NLRP3,CGRP,and eNOS are influencing factors for secondary intracranial infection and poor prognosis fol-lowing craniotomy for cerebral hemorrhage,exhibiting certain predictive values.关键词
Nod样受体蛋白3/降钙素基因相关肽/内皮型一氧化氮合酶/脑出血/开颅手术/继发颅内感染/预后/急性生理与慢性健康评分ⅡKey words
Nod-like receptor protein 3/calcitonin gene-related peptide/endothelial nitric oxide synthase/cerebral hemorrhage/craniotomy/secondary intracranial infection/prognosis/Acute Physiology and Chronic Health Evaluation Ⅱ分类
医药卫生引用本文复制引用
张佳乐,李传坤..血清Nod样受体蛋白3、降钙素基因相关肽以及内皮型一氧化氮合酶预测脑出血开颅手术后继发颅内感染及预后的价值[J].实用临床医药杂志,2025,29(16):40-45,6.基金项目
陕西省自然科学基础研究计划项目(2020JQ-509) （2020JQ-509）
