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TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy

Ruifang Luo Jie Chen Yuan Miao Riqiang Hu Fang Lin Junyan Yan Ting Yang Lu Xiao Zhujun Sun Yuting Wang

基因与疾病（英文）2025，Vol.12Issue(5)：430-445,16.

基因与疾病（英文）2025，Vol.12Issue(5)：430-445,16.DOI:10.1016/j.gendis.2025.101707

TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy

Ruifang Luo ¹Jie Chen ¹Yuan Miao ¹Riqiang Hu ¹Fang Lin ¹Junyan Yan ¹Ting Yang ¹Lu Xiao ²Zhujun Sun ¹Yuting Wang²

作者信息

1. Growth,Development and Mental Health Center of Children and Adolescents,Children's Hospital of Chongqing Medical University,Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing 404100,China
2. Digestive Department,Children's Hospital of Chongqing Medical University,Chongqing 404100,China
折叠

摘要

关键词

5-HT/Enterochromaffin cell/Intestinal motility/Prenatal LPS exposure/TLR4

Key words

5-HT/Enterochromaffin cell/Intestinal motility/Prenatal LPS exposure/TLR4

引用本文复制引用

Ruifang Luo,Jie Chen,Yuan Miao,Riqiang Hu,Fang Lin,Junyan Yan,Ting Yang,Lu Xiao,Zhujun Sun,Yuting Wang..TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy[J].基因与疾病（英文）,2025,12(5):430-445,16.

基金项目

This study was supported by the National Natural Science Foundation of China(No.82372559,31971089)and the General Project of Chongqing Natural Science Foundation(China)(No.CSTB2022NSCQ-MSX0107). （No.82372559,31971089）

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