实用临床医药杂志2025，Vol.29Issue(16)：51-55,5.DOI:10.7619/jcmp.20245462
百会穴和关元穴压灸联合丁苯酞对脑卒中恢复期患者认知功能的影响
Effect of pressure moxibustion at Baihui and Guanyuan acupoints combined with butylphthalide on cognitive function in stroke patients in recovery phase
摘要
Abstract
Objective To explore the application effect of pressure moxibustion at Baihui and Guanyuan acupoints combined with butylphthalide in treating stroke patients in recovery phase.Methods A total of 108 stroke patients in recovery phase were randomly divided into observation group and control group,with 54 cases in each group.The control group was treated with bu-tylphthalide on the basis of conventional treatment,while the observation group was treated with pres-sure moxibustion at Baihui and Guanyuan acupoints combined with butylphthalide for 8 consecutive weeks.After the end of the treatment course,the efficacy was evaluated in both groups,and the func-tional status[the National Institutes of Health Stroke Scale(NIHSS),the Montreal Cognitive Assess-ment(MoCA),the Barthel Index(BI)],event-related potential P300,the levels of hemodynamic indicators[resistance index(RI),pulsatility index(PI),mean velocity(Vm)],cognitive function markers[lipoprotein-associated phospholipase A2(Lp-PLA2),alkaline phosphatase(ALP),humanβ-amyloid 1-42(Aβ-42)]and safety were compared between the two groups before and after treat-ment.Results The total effective rate in the observation group was 96.30％,which was significantly higher than 85.19％in the control group(P＜0.05).After 8 weeks of treatment,the MoCA and BI scores in the observation group were significantly higher than those in the control group,while the NIHSS score was significantly lower(P＜0.05).After 8 weeks of treatment,the latency in the observation group was significantly lower than that in the control group,while the amplitude and the differences in latency and amplitude before and after treatment were significantly higher(P＜0.05).After 8 weeks of treatment,Vm in the observation group was significantly higher than that in the con-trol group,while PI and RI were significantly lower(P＜0.05).After 8 weeks of treatment,the levels of Lp-PLA2,ALP and Aβ-42 in the observation group were significantly lower than those in the control group(P＜0.05).No serious adverse reactions occurred in patients in each group.Conclusion Pressure moxibustion at Baihui and Guanyuan acupoints combined with butylphthalide can improve cerebral blood flow and promote the recovery of cognitive and neurological functions in stroke patients in recovery phase.The mechanism may be related to the downregulation of Lp-PLA2,ALP and Aβ-42 expression.关键词
脑卒中/压灸/丁苯酞/认知功能/穴位/脂蛋白相关磷脂酶A2/碱性磷酸酶/人β淀粉样蛋白1-42Key words
stroke/pressure moxibustion/butylphthalide/cognitive function/acupoints/lipoprotein-associated phospholipase A2/alkaline phosphatase/human β-amyloid 1-42分类
医药卫生引用本文复制引用
黄璇,崔洪涛,闫润润,赵然..百会穴和关元穴压灸联合丁苯酞对脑卒中恢复期患者认知功能的影响[J].实用临床医药杂志,2025,29(16):51-55,5.基金项目
河北省重点研发计划项目(20229006927D) （20229006927D）
