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Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2

Sadaf Hasan Nabil Ghani Xiangli Zhao Julia Good Chuan-ju Liu

基因与疾病（英文）2025，Vol.12Issue(5)：446-465,20.

基因与疾病（英文）2025，Vol.12Issue(5)：446-465,20.DOI:10.1016/j.gendis.2025.101571

Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2

Sadaf Hasan ¹Nabil Ghani ²Xiangli Zhao ³Julia Good ¹Chuan-ju Liu⁴

作者信息

1. Department of Orthopedic Surgery,New York University Grossman School of Medicine,New York,NY 10010,USA
2. Department of Medicine,Division of Internal Medicine,Saint Peter's University Hospital,Rutgers University,New Brunswick,NJ 08901,USA
3. Department of Orthopedic Surgery,New York University Grossman School of Medicine,New York,NY 10010,USA||Department of Orthopedics & Rehabilitation,Yale School of Medicine,New Haven,CT 06510,USA
4. Department of Orthopedic Surgery,New York University Grossman School of Medicine,New York,NY 10010,USA||Department of Cell Biology,New York University Grossman School of Medicine,New York,NY 10010,USA||Department of Orthopedics & Rehabilitation,Yale School of Medicine,New Haven,CT 06510,USA
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摘要

关键词

Colitis/Cytosolic phospholipase A2/Drug affinity-responsive target stability assay/Inflammation/Pyruvate/TNFα/NFκB signaling

Key words

Colitis/Cytosolic phospholipase A2/Drug affinity-responsive target stability assay/Inflammation/Pyruvate/TNFα/NFκB signaling

引用本文复制引用

Sadaf Hasan,Nabil Ghani,Xiangli Zhao,Julia Good,Chuan-ju Liu..Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2[J].基因与疾病（英文）,2025,12(5):446-465,20.

基金项目

This work was partially supported by the US National In-stitutes of Health(NIH)research grants R01AR062207,R01AR061484,R01AR076900,R01AR078035,and R01NS070328. （NIH）

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