华中科技大学学报（自然科学版）2025，Vol.53Issue(9)：33-39,7.DOI:10.13245/j.hust.250815
利用激光诱导电子衍射探测核酸分子结构
Laser-induced electron diffraction for molecular structural probing of nucleic acids
摘要
Abstract
In this work,laser-induced electron diffraction(LIED)was utilized to measure the molecular structures of ribonucleotide uracil(UMP)and deoxyribonucleotide thymine(dTMP).By simulating two-dimensional(2D)molecular contrast factor patterns at different incident electron energies and performing Fourier transforms on the contrast factors in momentum-transfer plane,the 2D molecular structures were successfully reconstructed,and the structural differences between the UMP and dTMP molecules were analyzed.Our theoretical results confirm that the obtained stable LIED signals over a broad range of electron energies are hopeful for rapidly and precisely detecting structural information and dynamic processes of biomolecules in bioelectronic devices.关键词
激光诱导电子衍射/分子结构测量/二维分子反差因子/傅里叶变换/生物分子Key words
laser-induced electron diffraction/molecular structure measurement/two-dimensional molecular contrast factor/Fourier transform/biomolecule分类
数理科学引用本文复制引用
王岩岩,余超,陆瑞锋..利用激光诱导电子衍射探测核酸分子结构[J].华中科技大学学报（自然科学版）,2025,53(9):33-39,7.基金项目
国家自然科学基金资助项目(12174195,12425411) （12174195,12425411）
武汉光电国家研究中心开放基金资助项目(2024WN-LOKF007). （2024WN-LOKF007）
