摘要
Abstract
Objective:To explore the influence of combined periodontal-orthodontic treatment on the levels of serum alkaline phosphatase,osteocalcin and osteoprotegerin in patients with anterior tooth displacement caused by periodontitis.Methods:Fifty-four patients with displaced anterior teeth caused by periodontitis who were treated in our hospital from May 2022 to May 2024 were selected as the research subjects.All patients were given combined periodontal-orthodontic treatment.Before treatment,the levels of serum alkaline phosphatase,osteocalcin and osteoprotegerin in all patients with displaced ante-rior teeth caused by periodontitis were evaluated.The patients were followed up continuously for 12 months after the opera-tion,the therapeutic effect was evaluated.Fifty-four patients with anterior tooth displacement caused by periodontitis who a-chieved significant therapeutic effects were included in the effective group(50 cases).Those with no therapeutic effect were included in the ineffective group(4 cases).The levels of serum alkaline phosphatase,osteocalcin and osteoprotegerin between the two groups were compared.Logistic regression was used to analyze the relationship between serum alkaline phosphatase,osteocalcin,osteoprotegerin and the effect of periodontitis-evidence combined treatment on patients with anterior tooth dis-placement caused by periodontitis.To analyze the value of serum alkaline phosphatase,osteocalcin and osteoprotegerin in e-valuating the effect of combined periodontal-orthodontic treatment on patients with anterior tooth displacement caused by peri-odontitis.Results:Before treatment,there was no statistically significant difference in the levels of serum alkaline phospha-tase,osteocalcin and osteoprotegerin between the two groups(P>0.05).After treatment,the levels of various indicators in both groups were higher than those before treatment,and those in the effective group were higher than in the ineffective group(P<0.05).The effect of combined periodontal-orthodontic treatment for patients with anterior tooth displacement caused by periodontitis was taken as the dependent variable(0=treatment ineffective,1=treatment effective).Serum alkaline phospha-tase,osteocalcin and osteoprotegerin were taken as covariates.Logistic regression analysis shows that,the levels of serum alka-line phosphatase,osteocalcin and osteoprotegerin were correlated with the therapeutic effect of patients with anterior tooth dis-placement caused by periodontitis(P<0.05).The AUC,Youden index,specificity and sensitivity of the combined diagnosis for evaluating the effect of combined periodontal-orthodontic treatment on patients with anterior tooth displacement caused by periodontitis were significantly higher than single indicator.Conclusion:The combined periodontal-orthodontic treatment for patients with anterior tooth displacement caused by periodontitis can increase the levels of serum alkaline phosphatase,osteo-calcin and osteoprotegerin,and the therapeutic effect is obvious.关键词
碱性磷酸酶/骨钙素/骨保护素/牙周-正畸联合治疗/牙周炎致前牙移位/效果Key words
Alkaline phosphatase/Osteocalcin/Osteoprotectin/Combined periodontal-orthodontic treatment/Anterior tooth displacement due to periodontitis/Effect分类
医药卫生
