西南医科大学学报2025，Vol.48Issue(5)：460-464,5.DOI:10.3969/j.issn.2096-3351.2025.05.004
宫腔微生态系统与子宫内膜病变的研究进展
Research Progress on the Microecosystem of the Uterine Cavity and Endometrial Lesions
摘要
Abstract
Traditionally,the uterine cavity was considered to be sterile.However,in recent years,with the application of tech-niques such as quantitative PCR and 16S rRNA,studies have found that there is bacterial colonization in the uterine cavity.Researches have showed that the endometrial microbiota is associated with a variety of gynecological diseases,including endometriosis,endometri-tis,endometrial hyperplasia,and endometrial cancer,etc.However,it is still unclear whether the imbalance of the endometrial micro-ecology is the cause or the result of the disease.This article reviewed the research progress on the microecosystem of the uterine cavity and endometrial lesions.This article explores the correlation between the vaginal microbiota and the endometrial microbiota,pointing out that the female reproductive tract is a continuous microecological system.Lactobacillus plays a key role in maintaining the microeco-logical balance of the vagina and cervix,while the composition and diversity of the endometrial microbiota vary under different physi-ological states.In addition,the endometrial microbiota is closely related to endometrial inflammatory diseases.In an inflammatory state,the diversity of the microbiota increases,and the proliferation of harmful bacteria exacerbates the condition.In endometriosis,the microbial diversity in the uterine cavity is richer,which may promote the development of the disease by changing the local microen-vironment,disrupting hormonal metabolism,and causing abnormal immune regulation.The imbalance of the microbiome can affect embryo implantation and pregnancy results.Future research needs to introduce technologies such as high-throughput sequencing to clarify the composition of the endometrial microecology and develop new treatment strategies,such as probiotics or immunotherapy,to improve female reproductive health.关键词
宫腔微生态/子宫内膜炎/阴道菌群/妊娠结局/微生物组Key words
Microecology of the uterine cavity/Endometritis/Vaginal microbiota/Pregnancy outcome/Microbiome分类
医药卫生引用本文复制引用
王奔,韩健,袁艺萍,王月洪,黄畅晓,李力..宫腔微生态系统与子宫内膜病变的研究进展[J].西南医科大学学报,2025,48(5):460-464,5.基金项目
国家自然科学基金(31470886) （31470886）
重庆市自然科学基金项目(cstc2019jcyj-msxmX0449) （cstc2019jcyj-msxmX0449）
军队计生专项(21JSZ03,22JSZ01) （21JSZ03,22JSZ01）
