岭南现代临床外科2025，Vol.25Issue(4)：258-266,9.DOI:10.3969/j.issn.1009-976X.2025.04.008
细胞焦亡在甲状腺癌中的双向效应及靶向治疗研究进展
Pyroptosis in thyroid cancer:dual roles and advances in therapeutic interventions
摘要
Abstract
Pyroptosis is a novel type of programmed cell death mode.It mediates membrane pore formation and pro-inflammatory factor release through Gasdermin family proteins and shows a bidirectional effect of promoting and inhibiting cancer in thyroid cancer.The standard therapeutic effect of thyroid cancer is still limited.Exploring the application of pyroptosis mechanism in tumor suppression and immune activation has become a new research direction.This article summarizes the differences in the role of pyroptosis in different thyroid cancer subtypes and the tumor immune microenvironment,Outlines the research progress of drug-induced pyroptosis such as chemotherapy,targeted therapy,and traditional Chinese medicine components,and looks forward to the potential of pyroptosis regulation in precision treatment.关键词
细胞焦亡/甲状腺癌/肿瘤免疫微环境/药物干预Key words
pyroptosis/thyroid cancer/tumor immune microenvironment/drug intervention分类
医药卫生引用本文复制引用
金欣茹,赵子逸,钟树文,吴贤江..细胞焦亡在甲状腺癌中的双向效应及靶向治疗研究进展[J].岭南现代临床外科,2025,25(4):258-266,9.基金项目
宁波市公益基金(2023S139) （2023S139）
