摘要
Abstract
Objective To investigate the efficacy of dual-target combined anticoagulation therapy of dabigatran and ri-varoxaban in elderly patients with atrial fibrillation(AF)complicated with stroke.Methods 120 elderly AF patients with stroke admitted to People's Hospital of Yanting County from January 2022 to December 2023 were selected and randomly divid-ed into combined anticoagulation group(n=60,treated with dabigatran combined with rivaroxaban)and control group(n=60,treated with dabigatran)by a random number table method.Both groups were treated continuously for 6 months.The co-agulation function,liver and kidney function,and adverse events within one year were compared between the two groups.Results After treatment,the prothrombin time(PT),thrombin time(TT),and partial thromboplastin time(APTT)in both groups were longer than those in the same group before treatment(P＜0.05),and the combined anticoagulation group was lon-ger than the control group(P＜0.05).Before and after treatment,there was no statistically significant difference in the levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)between the two groups(P＞0.05).After treat-ment,the creatinine(SCr)level in the combined anticoagulation group increased and was higher than that in the control group(P＜0.05).During the 1-year follow-up,the total incidence of thromboembolism in the combined anticoagulation group was lower than that in the control group(P＜0.05),but the incidence of bleeding events was significantly higher than that in the control group(P＜0.05).Conclusion The dual-target combined anticoagulation therapy of dabigatran and rivaroxaban has a good effect on elderly patients with AF complicated with stroke.It can effectively improve the coagulation function and reduce the incidence of thromboembolic events,but it may relatively increase the risk of bleeding.关键词
老年/房颤合并卒中/达比加群/利伐沙班/抗凝治疗/凝血功能/出血风险Key words
elderly/atrial fibrillation complicated with stroke/dabigatran/rivaroxaban/anticoagulant therapy/coagula-tion function/risk of bleeding
