国际眼科杂志2025，Vol.25Issue(10)：1592-1597,6.DOI:10.3980/j.issn.1672-5123.2025.10.08
铁死亡在青光眼中的作用机制及研究进展
Mechanisms and research progress of ferroptosis in glaucoma
摘要
Abstract
Ferroptosis,an iron-dependent form of programmed cell death characterized by lipid peroxidation,oxidative stress,and dysregulated iron metabolism,plays a significant role in the pathogenesis of glaucoma.This review systematically summarizes the fundamental mechanisms of ferroptosis,the involvement of oxidative stress and ferroptosis in glaucoma,the relationship between ferroptosis and glaucomatous neurodegeneration,and the potential therapeutic strategies targeting ferroptosis in glaucoma.Studies have shown that ferroptosis-regulating factors play a crucial role in mitigating oxidative damage and preserving cellular function.However,the complexity of their regulatory mechanisms not only hinders a comprehensive understanding of their roles but also impedes clinical translation.Although ferroptosis inhibitors have demonstrated promising neuroprotective effects in animal models,their clinical application remains challenged by issues such as drug safety and target specificity.Therefore,the development of more targeted and low-toxicity therapeutic strategies is essential to advance personalized and precise treatment for glaucoma.关键词
铁死亡/青光眼/氧化应激/脂质过氧化/视神经损伤Key words
ferroptosis/glaucoma/oxidative stress/lipid peroxidation/optic nerve injury引用本文复制引用
徐飞扬,徐帆..铁死亡在青光眼中的作用机制及研究进展[J].国际眼科杂志,2025,25(10):1592-1597,6.基金项目
国家自然科学基金项目(No.82060179,82460207) （No.82060179,82460207）
广西重点研发计划项目(No.桂科AB24010171) （No.桂科AB24010171）
广西卫健委自筹课题项目(No.Z20200830) National Natural Science Foundation of China(No.82060179,82460207) （No.Z20200830）
Guangxi Key Research and Development Program(No.GuiKeAB24010171) （No.GuiKeAB24010171）
Guangxi Health Commission Self-Funded Project(No.Z20200830) （No.Z20200830）
