国际眼科杂志2025，Vol.25Issue(10)：1598-1603,6.DOI:10.3980/j.issn.1672-5123.2025.10.09
cAMP/PKA信号通路在青光眼性视神经病变中的研究进展
Research progress of cAMP/PKA signaling pathway in glaucoma optic neuropathy
摘要
Abstract
Glaucoma is a multifactorial degenerative optic neuropathy,and its irreversible and blinding pathological characteristics mainly come from the damage to the optic nerve,namely glaucomatous optic neuropathy(GON).The difficulty in the treatment of GON lies in the early intervention,and currently there is no optic neuroprotective drug for the treatment of all types of GON.The death of retinal ganglion cells(RGCs)is the core pathological change caused by various pathogenic mechanisms of GON.Recent studies have found that the widespread second messenger cyclic adenosine 3',5'-monophosphate(cAMP)and its downstream effector protein kinase A(PKA)signal cascade play an important role in the pathogenesis of GON.It can also inhibit the apoptosis of RGCs and play a protective and therapeutic role in glaucoma.Therefore,this article reviews the role of cAMP/PKA pathway in the pathophysiological development of GON,focusing on its effects on glaucoma intraocular pressure regulation,oxidative stress,neuroinflammation and optic nerve degeneration,in order to find a common central regulatory target for the optic nerve damage caused by different pathological mechanisms of GON and promote the further understanding and clinical treatment of this disease.关键词
环磷酸腺苷(cAMP)/蛋白激酶A(PKA)/青光眼/青光眼性视神经病变/视网膜神经节细胞/凋亡Key words
cyclic adenosine 3',5'-monophosphate(cAMP)/protein kinase A(PKA)/glaucoma/glaucomatous optic neuropathy/retinal ganglion cells/apoptosis引用本文复制引用
崔宏达,黄雨,夏鑫,李江伟,彭清华..cAMP/PKA信号通路在青光眼性视神经病变中的研究进展[J].国际眼科杂志,2025,25(10):1598-1603,6.基金项目
国家自然科学基金资助项目(No.82274588) （No.82274588）
国家中医药管理局人才支持项目[国中医药人教函(2022)6号] （2022）
湖南省教育厅科研创新项目(No.CX20230790) National Natural Science Foundation of China(No.82274588) （No.CX20230790）
Talent Support Project of the State Administration of Traditional Chinese Medicine[Chinese Medicine Teaching Letter(2022)6] （2022）
Scientific Research Innovation Project of Hunan Education Department(No.CX20230790) （No.CX20230790）
