国际眼科杂志2025，Vol.25Issue(10)：1604-1610,7.DOI:10.3980/j.issn.1672-5123.2025.10.10
细胞自噬在视神经损伤中的研究进展
Research progress on autophagy in optic nerve injury
摘要
Abstract
The damage and death of retinal ganglion cells(RGCs)are central pathological events in optic nerve injury,leading to irreversible visual impairment.Autophagy,a regulated process of cellular degradation and death,is involved in the pathogenesis of various diseases,including tumors,neurological damage,and autoimmune disorders.Current research indicates that autophagy is significantly upregulated following optic nerve injury,exhibiting a dual role:while it may mediate cellular damage in the early stages,it tends to promote neuroprotection and axonal regeneration in later phases.Moreover,the activation of autophagy in microglia may play a crucial role in regulating their activation phenotype and neuroinflammation.Precisely modulating autophagy to promote RGCs survival and improve visual function has become a key challenge in the treatment of optic nerve injury.This review summarizes the role of autophagy in optic nerve injury and its therapeutic interventions.关键词
自噬/视神经损伤/视神经节细胞Key words
autophagy/optic nerve injury/retinal ganglion cells引用本文复制引用
柯舒萍,黄梓敬..细胞自噬在视神经损伤中的研究进展[J].国际眼科杂志,2025,25(10):1604-1610,7.基金项目
国家自然科学基金资助项目(No.82101112,82471082) National Natural Science Foundation of China(No.82101112,82471082) （No.82101112,82471082）
