南华大学学报（自然科学版）2025，Vol.39Issue(3)：77-85,9.DOI:10.19431/j.cnki.1673-0062.2025.03.011
基于免疫检查点抑制剂的肿瘤免疫模型动力学分析
Dynamic Analysis of a Tumor-Immune Model Based on Immune Checkpoint Inhibitors
欧映辰 1朱惠延1
作者信息
- 1. 南华大学 数理学院,湖南 衡阳 421001
- 折叠
摘要
Abstract
Anti-PD-1,an immune checkpoint inhibitor,is an emerging immunotherapy aimed at counteracting tumor immune evasion mechanisms.This paper presents a three-di-mensional ordinary differential equation tumor-immune model containing the rabbit epidemic checkpoint inhibitor anti-PD-1.Through dynamic analysis of the model,it is ob-served that,in the absence of treatment,the system always has a unique tumor-free equi-librium point and at most two tumor equilibrium points.By applying the Dulac function,it is rigorously demonstrated that no nontrivial positive periodic orbits exist under untreated conditions,thereby establishing the global dynamical behavior of the system in the absence of therapeutic intervention.The research results show that both the possibility parameter p of T cells killing tumor vesicles and the activation of T vesicles with anti-PD-1 inhibitors can effectively inhibit tumor vesicles.关键词
肿瘤免疫模型/免疫检查点抑制剂anti-PD-1/动力学Key words
tumor immune model/immune checkpoint inhibitor anti-PD-1/dynamics分类
数理科学引用本文复制引用
欧映辰,朱惠延..基于免疫检查点抑制剂的肿瘤免疫模型动力学分析[J].南华大学学报（自然科学版）,2025,39(3):77-85,9.
