日用化学品科学2025，Vol.48Issue(9)：27-34,8.DOI:10.3969/j.issn.1006-7264.2025.09.005
橄榄油神经酰胺对皮肤屏障的舒缓修护功效
Soothing and repairing effects of olive oil-derived ceramide NP on the skin barrier
王静一 1王洁琦 1陶侃 1常怀龙1
作者信息
- 1. 上海上美化妆品股份有限公司,上海 200333||上海红色小象化妆品有限公司,上海 201802
- 折叠
摘要
Abstract
Ceramides are critical components of human skin,with their structural composition—particularly the distribution of fatty acid chain lengths—playing a key role in determining their functional properties.The fatty acid chain length distribution in plant oils closely resembles that of ceramides in the stratum corneum.In this study,ceramide NP with fatty acid chains ranging from C16 to C24 was synthesized using Longnan extra virgin olive oil as a fatty acid donor.Transcriptomic analysis was employed to evaluate the protective effects of olive oil-derived ceramide NP on the skin barrier under UVB exposure,including enrichment analysis of differentially expressed genes.In addition,an SLS-induced epidermal skin model was used to assess impacts on inflammatory factor expression,tissue morphology,and levels of barrier-related proteins.Results indicated that olive oil-derived ceramide NP exerted soothing and reparative effects by inhibiting inflammation-related signaling pathways,reducing inflammatory mediator secretion,maintaining tissue integrity,and upregulating barrier-associated proteins.Compared with stearic acid-derived ceramides(which contain a single fatty acid chain length),olive oil-derived ceramide NP showed significantly enhanced efficacy at equivalent concentrations.关键词
橄榄油/神经酰胺/敏感肌/皮肤屏障/转录组学Key words
olive oil/ceramide NP/sensitive skin/skin barrier/transcriptomics分类
化学化工引用本文复制引用
王静一,王洁琦,陶侃,常怀龙..橄榄油神经酰胺对皮肤屏障的舒缓修护功效[J].日用化学品科学,2025,48(9):27-34,8.
