日用化学品科学2025，Vol.48Issue(9)：35-42,8.DOI:10.3969/j.issn.1006-7264.2025.09.006
吡咯并喹啉醌二钠盐延缓皮肤衰老功效及作用机制探究
Investigation into the anti-aging effects and mechanism of action of pyrroloquinoline quinone disodium salt
张秋玲 1张钰莹 1陈浩 1肖清炜 2张廷志 2颜少慰1
作者信息
- 1. 熬夜肌实验室系统工程(上海)有限公司,上海 200125
- 2. 水羊化妆品制造有限公司,湖南 长沙 410000
- 折叠
摘要
Abstract
This study explores the anti-aging effects and mechanisms of pyrroloquinoline quinone disodium salt(PQQ-Na2)through a series of in vitro and in vivo experiments,including oxidative stress assays in human immortalized keratinocytes,assessment of mitochondrial function and collagen expression in human immortalized fibroblasts,and efficacy evaluations on human skin.The results showed that in keratinocytes,PQQ-Na₂ promoted the expression of Nrf2 and HO-1,reduced intracellular reactive oxygen species(ROS)levels,and enhanced resistance to oxidative stress.Compared with conventional antioxidants,PQQ-Na₂ demonstrated superior antioxidant capacity.In fibroblasts,PQQ-Na2 decreased mitochondrial superoxide levels,increased the proportion of active mitochondria,and restored mitochondrial function.Furthermore,PQQ-Na2 significantly upregulated the expression of collagen types IV,VII,and XVIII in the basement membrane,indicating a strong anti-aging effect at the dermal-epidermal junction.Human skin tests further confirmed the significant anti-aging efficacy of PQQ-Na₂.关键词
吡咯并喹啉醌二钠盐/抗氧化/线粒体/皮肤衰老Key words
pyrroloquinoline quinone disodium salt/antioxidant/mitochondria/skin aging分类
化学化工引用本文复制引用
张秋玲,张钰莹,陈浩,肖清炜,张廷志,颜少慰..吡咯并喹啉醌二钠盐延缓皮肤衰老功效及作用机制探究[J].日用化学品科学,2025,48(9):35-42,8.
