日用化学品科学2025，Vol.48Issue(9)：50-55,6.DOI:10.3969/j.issn.1006-7264.2025.09.008
不同分子量透明质酸的体外修护功效研究
Study on in vitro repair effect of hyaluronic acids in different molecular weights
陈鑫 1王晓娜 1韩婷婷 1宁辉 1姜良艳 1王晓霞1
作者信息
- 1. 山东福瑞达生物股份有限公司,山东 济南 250101
- 折叠
摘要
Abstract
In order to explore the repair efficacy of three different molecular weights of hyaluronic acids(HAs),the experiments were carried out from the cellular level to conduct cytotoxicity tests on three different molecular weights of HAs in keratin-forming cells.The results showed that the critical concentrations of high,medium and low molecular weight HAs were 2.5,0.625 and 5 mg/mL respectively.The repair effect was verified using a 3D epidermal skin model after the treatment with HAs in different molecular weights.The results showed that there were differences in the repair effect of HA of different molecular weights,where the high molecular weight HA has the best effect on increasing the content of chitin and ceramide;The medium molecular weight HA has the best effect on enhancing silk fibroin;The effect of small molecular weight HA has best effect on increasing the content of tight junction protein-1 and hyaluronic acid receptor CD44.关键词
不同分子量透明质酸/修护功效/3D表皮皮肤模型Key words
hyaluronic acid with different molecular weights/repair benefit/3D epidermal skin model分类
化学化工引用本文复制引用
陈鑫,王晓娜,韩婷婷,宁辉,姜良艳,王晓霞..不同分子量透明质酸的体外修护功效研究[J].日用化学品科学,2025,48(9):50-55,6.
