药学研究2025，Vol.44Issue(8)：737-742,755,7.DOI:10.13506/j.cnki.jpr.2025.08.002
赤芝的化学成分及其抗三阴性乳腺癌活性研究
Chemical constituents from Ganoderma lucidum and their anti-triple negative breast cancer activities
摘要
Abstract
Objective To investigate the chemical constituents of Ganoderma lucidum and evaluate their anti-triple negative breast cancer activities.Methods The structures were isolated using diverse column chromatography techniques from the fruiting bodies of Ganoderma lucidum and identified by 1D,2D NMR and HRESIMS data.Compounds that can in-hibit MDA-MB-231 cells proliferation were initially screened through CCK-8 and IC50 assay.Results Five new compounds were isolated from the ethyl acetate fraction of the 80％ethanol extract of G.lucidum.The structures were identi-fied as bslingzhines A～E(1～5).The IC50 of compound 5 was calculated to be 61.01 μmol·L-1.Conclusion Compounds 1～5 are new lanostane triterpenoids with weak or without in vitro anti-tumor ability.关键词
赤芝/化学成分/羊毛脂甾烷三萜/三阴性乳腺癌Key words
Ganoderma lucidum/Chemical constituents/Lanostane triterpenoid/Triple negative breast cancer分类
医药卫生引用本文复制引用
许宸,高强,程永现..赤芝的化学成分及其抗三阴性乳腺癌活性研究[J].药学研究,2025,44(8):737-742,755,7.基金项目
国家自然科学基金项目(No.82030115) （No.82030115）
