药学研究2025，Vol.44Issue(8)：779-785,7.DOI:10.13506/j.cnki.jpr.2025.08.009
外侧下丘脑GABA能神经元的功能研究进展
Research progress on the function of GABAergic neurons in lateral hypothalamus
摘要
Abstract
The lateral hypothalamic area(LHA)is a structurally and functionally heterogeneous central regulatory hub.Recent advancements in neurotechnological tools,particularly the application of optogenetic manipulation and trans-synaptic neural circuit tracing techniques,have enabled researchers to progressively decipher the key mechanisms of how the LHA regulates diverse physiological processes via cell type-specific neural circuits.Among its neuronal subpopulations,GABAergic neurons in the LHA serve as core inhibitory regulatory units,critically implicated in maintaining dynamic critically implicated in feeding,maintaining by namic equilibrium of energy metabolism,orchestrating circadian modulation of sleep-wake cycles,and integrating emotional-motivational behaviors.Dysfunction of GABAergic neuronal populations in the LHA has been confirmed as a critical contributor to the pathogenesis and progression of multiple disorders,including obesity,sleep disorders,depression,and drug addiction.This review synthesized cutting-edge discoveries in the field,providing an in-depth exploration of the functional architecture of LHA GABAergic neurons and their circuit-based mechanisms,while offering novel perspectives for mechanistic research and therapeutic target identification in related neuropsychiatric disorders.关键词
外侧下丘脑/GABA能神经元/神经生物学功能Key words
Lateral hypothalamus/GABAergic neurons/Neurobiological functions分类
医药卫生引用本文复制引用
张诗雅,洪浩..外侧下丘脑GABA能神经元的功能研究进展[J].药学研究,2025,44(8):779-785,7.基金项目
国家自然科学基金面上项目(No.82173805) （No.82173805）
科技创新2030-"脑科学与类脑研究"重大专项(No.2021ZD0203400) （No.2021ZD0203400）
