药学研究2025，Vol.44Issue(8)：786-792,832,8.DOI:10.13506/j.cnki.jpr.2025.08.010
黄芩保肝活性成分及作用机制研究进展
Research progress on the hepatoprotective active components and mechanisms of Scutellaria baicalensis
摘要
Abstract
Scutellaria baicalensis,a widely utilized traditional Chinese medicine,is recognized for its properties in clearing heat and drying dampness,as well as eliminating fire and detoxifying the body.Its primary active constituents encompass flavonoids,flavonol glycosides,volatile oils,and polysaccharides,with flavonol glycosides,particularly baicalin and wogonoside,being the most significant.Extensive researches by numerous scientists have delved into the efficacy of Scutellaria baicalensis in addressing liver diseases.Studies indicate that the flavonoid and flavonol glycoside components within Scutellaria baicalensis exhibit notable therapeutic benefits in managing viral hepatitis,alcoholic liver disease,non-alcoholic fatty liver disease(NAFLD),non-alcoholic steatohepatitis(NASH),cirrhosis,hepatocellular carcinoma(HCC),and drug-induced liver injury.These compounds effectively lower serum transaminase levels in animal models of liver injury,mitigate hepatic pathological alterations,and diminish the intensity of inflammatory reactions,thereby contributing to liver health preservation.The underlying mechanisms are multifaceted,primarily comprising anti-oxidative,anti-inflammatory,anti-fibrotic actions,as well as lipid metabolism modulation and immune regulation.Such research outcomes furnish a robust theoretical foundation and promising prospects for the clinical application of Scutellaria baicalensis in liver disease treatment.This paper aimed to systematically review the active components of Scutellaria baicalensis along with their potential mechanisms in hepatic protection to provide valuable insights for clinical applications of Scutellaria baicalensis in hepatoprotection and the development of novel hepatoprotective agents.关键词
黄芩/保肝/活性成分/作用机制Key words
Scutellaria baicalensis/Hepatic protection/Active components/Action mechanisms分类
医药卫生引用本文复制引用
吴浩,刘晓倩,朱日然..黄芩保肝活性成分及作用机制研究进展[J].药学研究,2025,44(8):786-792,832,8.基金项目
2023年全国中药特色技术传承人才培训项目(No.T20234832005) （No.T20234832005）
山东中医药学会临床药学科研专项基金项目(No.SDACM202204) （No.SDACM202204）
山东省医药卫生科技项目(No.202313010888) （No.202313010888）
