兰州大学学报（医学版）2025，Vol.51Issue(7)：38-45,8.DOI:10.13885/j.issn.2097-681X.2025.07.006
乙型肝炎肝硬化患者脑功能改变的图论分析
Graph theory analysis of alterations in brain functional in patients with hepatitis B cirrhosis
摘要
Abstract
Objective To investigate whether alterations in topological properties of brain functional networks and abnormal functional connectivity occur in patients with hepatitis B cirrhosis,and to evaluate the associa-tion between these topological features and cognitive performance in cirrhotic patients.Methods This study enrolled 32 clinically diagnosed patients with hepatitis B cirrhosis(from the Department of Infectious Diseas-es,The First Hospital of Lanzhou University,November 2023 to November 2024)as the cirrhosis group,along with 31 healthy volunteers recruited as the control group.All participants underwent brain magnetic resonance imaging(MRI)scanning and comprehensive neuropsychological assessments.The United Imaging Intelli-gence and MATLAB R2024a were utilized to analyze 3D T1-weighted imaging and blood oxygen level-depen-dent functional magnetic resonance imaging data.Differences in network topological properties and functional connectivity between the two groups were compared,and correlations between topological features and cog-nitive performance in cirrhosis patients were analyzed.Results Compared to the control group,hepatitis B cirrhosis patients exhibited significant reductions in mean local efficiency(F=6.316,P=0.015)and clustering coefficient(F=5.187,P=0.026).A decreasing trend in topological properties was observed in specific nodes,though these differences were not statistically significant after multiple comparison corrections(P>0.05).Cirrhosis patients exhibited one subnetwork with significantly enhanced functional connectivity and two subnetworks with significantly reduced functional connectivity(P<0.05).Conclusion Hepatitis B cirrhosis disrupts the topological organization of brain functional networks.Analysis of the brain network level may contribute to a more comprehensive and macro-level understanding of the neuropathological mechanisms underlying cognitive deficits in these patients.关键词
乙型肝炎病毒/肝硬化/磁共振成像/图论/脑网络拓扑属性/认知功能障碍/功能连接Key words
hepatitis B virus/liver cirrhosis/magnetic resonance imaging/graph theory/brain network topolo-gy property/cognitive disorder/functional connectivity分类
医药卫生引用本文复制引用
任虎玲,苟露斌,高玉岭,王彦斐,兰金辉,李鹏强,窦郁,雷军强..乙型肝炎肝硬化患者脑功能改变的图论分析[J].兰州大学学报（医学版）,2025,51(7):38-45,8.基金项目
甘肃省科技计划资助项目(20JR11RA026) （20JR11RA026）
兰州市科技计划资助项目(2024-9-107) （2024-9-107）
兰州大学第一医院院内基金资助项目(ldyyyn2023-96) （ldyyyn2023-96）
