首页|期刊导航|世界急诊医学杂志（英文）|Activation of the α7 nicotinic acetylcholine receptor mitigates cognitive deficits in mice with sepsis-associated encephalopathy by inhibiting microglial pyroptosis

Activation of the α7 nicotinic acetylcholine receptor mitigates cognitive deficits in mice with sepsis-associated encephalopathy by inhibiting microglial pyroptosis

Qiaosheng Wang Qiong Luo Zhiwei Su Yan Xu Liangshan Peng Yin Wen Hongke Zeng Hongguang Ding

世界急诊医学杂志（英文）2025，Vol.16Issue(5)：438-446,9.

世界急诊医学杂志（英文）2025，Vol.16Issue(5)：438-446,9.DOI:10.5847/wjem.j.1920-8642.2025.099

Activation of the α7 nicotinic acetylcholine receptor mitigates cognitive deficits in mice with sepsis-associated encephalopathy by inhibiting microglial pyroptosis

Qiaosheng Wang ¹Qiong Luo ¹Zhiwei Su ²Yan Xu ¹Liangshan Peng ¹Yin Wen ²Hongke Zeng ²Hongguang Ding³

作者信息

1. Department of Critical Care Medicine,the First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang 421001,China
2. Department of Critical Care Medicine,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China
3. Department of Emergency Medicine,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China
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摘要

关键词

Sepsis-associated encephalopathy/α7 nicotinic acetylcholine receptor/Mitophagy/Pyroptosis

Key words

Sepsis-associated encephalopathy/α7 nicotinic acetylcholine receptor/Mitophagy/Pyroptosis

引用本文复制引用

Qiaosheng Wang,Qiong Luo,Zhiwei Su,Yan Xu,Liangshan Peng,Yin Wen,Hongke Zeng,Hongguang Ding..Activation of the α7 nicotinic acetylcholine receptor mitigates cognitive deficits in mice with sepsis-associated encephalopathy by inhibiting microglial pyroptosis[J].世界急诊医学杂志（英文）,2025,16(5):438-446,9.

基金项目

This study was supported by grants from the Natural Science Foundation of Hunan Province(2022JJ70037 and 2022JJ40402),the National Natural Science Foundation of China(82472220 and 82002074),the Natural Science Foundation of Guangdong Province(2023A1515010267,2023A1515012665 and 2024A1515010073),and the China International Medical Foundation Cerebrovascular Disease Youth Innovation Fund(Z-2016-20-2201). （2022JJ70037 and 2022JJ40402）

世界急诊医学杂志（英文）

ISSN：1920-8642

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